The development of the stria vascularis in the human cochlea was studied in step sections of 81 human foetal temporal bones. The stria vascularis primordium can be identified as a ridge of epithelial cells on the lateral wall of the cochlear duct. The first signs of differentiation appear at the 11th week, but it is not until the 17th-18th week that the typical trilaminar structure is observed. The appearance of similar cells with notched nuclei in both marginal and mesenchymal layers at this stage suggests the possibility that some of the intermediate cells may be of epithelial origin. By the 21st week, the overall appearance resembles that of the adult structure. This occurs 1 week after the opening of the tunnel of Corti, and possibly marks the onset of cochlear function.
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http://dx.doi.org/10.1046/j.1365-2273.2000.00340.x | DOI Listing |
Tissue Cell
December 2024
ENT Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. Electronic address:
Background: Sensorineural hearing loss (SNHL) is the most common sensory deficit worldwide. Current solutions for SNHL, including hearing aids, cochlear implants, and hearing assistive devices, do not provide consistent results and fail to address the underlying pathology of hair cell and ganglion cell damage. Stem cell therapy is a cornerstone in regenerative medicine.
View Article and Find Full Text PDFOtolaryngol Head Neck Surg
December 2024
Department of Otorhinolaryngology, Gazi University Faculty of Medicine, Ankara, Turkey.
Objective: This study aimed to attenuate cochlear inflammation following noise-induced hearing loss by targeting IL-1. We evaluated the effectiveness of IL-1 inhibition through auditory and histological assessments in an animal model.
Study Design: Experimental animal study.
Background: Hearing loss affects over 10% of the global population. Inflammation is a key factor in hearing loss caused by noise, infection, and aging, damaging various hearing-related tissues (e.g.
View Article and Find Full Text PDFIndian Dermatol Online J
September 2024
Department of ENT and Head and Neck Surgery, All India Institute of Medical Sciences, Guntur, Andhra Pradesh, India.
Background: Melanocytes in the hair and melanocytes in the stria vascularis of the inner ear have common origins. Many congenital and acquired disorders of cutaneous pigmentation have auditory abnormalities. There is a paucity of studies on the auditory associations of early graying.
View Article and Find Full Text PDFNeuroradiol J
November 2024
Department of Radiology, Massachusetts General Hospital, USA.
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