To improve the laser welding procedure, a comparative study was undertaken to investigate the acute bonding strength and the thermal damage following CO2 and Nd:YAG laser-assisted nerve repair, performed with and without the use of blood and/or albumin as a solder. The strongest welds were produced with the CO2 laser using albumin as a solder. Thermal damage was minimal with the CO2 laser, whereas the damage with the Nd:YAG laser was substantial. The high bonding strength combined with minimal thermal damage of the nerve following repair with the CO2 laser with the use of albumin justify further investigations using this technique in in vivo studies.
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