Efficient palladium-catalyzed N-arylation of indoles.

Org Lett

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Published: May 2000

[equation--see text] The N-arylation of indoles, including a variety of substituted ones, has been carried out using bulky, electron-rich phosphines as the supporting ligand in combination with Pd(2)(dba)(3). Using this catalyst system, the efficient coupling of indole and a variety of substituted indoles with aryl iodides, bromides, chlorides, and triflates can be achieved.

Download full-text PDF

Source
http://dx.doi.org/10.1021/ol005728zDOI Listing

Publication Analysis

Top Keywords

n-arylation indoles
8
variety substituted
8
efficient palladium-catalyzed
4
palladium-catalyzed n-arylation
4
indoles [equation--see
4
[equation--see text]
4
text] n-arylation
4
indoles including
4
including variety
4
substituted carried
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!