AI Article Synopsis
- The compound 3-(2-Aminophenylthio)prop-1-yne reacts with various aryl iodides using palladium-copper catalysis to produce disubstituted alkynes.
- After undergoing tosylation, these alkynes enter a unique cyclization process mediated by copper, resulting in the formation of 2-substituted benzothiazolines.
- Interestingly, the anticipated product of 3-(arylidine)-2,3-dihydrobenzothiazines was not achieved in this process.
Article Abstract
[reaction: see text] 3-(2-Aminophenylthio)prop-1-yne 8 reacted with aryl iodides 9-18 under palladium-copper catalysis leading to the disubstituted alkynes 19-28 which after tosylation underwent a novel cyclization under copper catalysis to 2-substituted benzothiazolines 29-38. The expected 3-(arylidine)-2,3-dihydrobenzothiazines were not obtained.
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| http://dx.doi.org/10.1021/ol990165g | DOI Listing |
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