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Regulation of anaplerotic enzymes by melatonin enhances resilience to cadmium toxicity in Vigna radiata (L.) R. Wilczek.
Plant Physiol Biochem
January 2025
Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
Melatonin (Mel) is a tryptophan-derived (N-acetyl-5-methoxytryptamine) molecule. In the present study, role of Mel in the regulation of various anaplerotic enzymes is discussed in relation to N metabolism and H-ATPase activity in mung bean under Cd stress. The application of Mel to the Cd-stressed mung bean seedlings was remarkable in improving the activity of hexokinase (35.
View Article and Find Full Text PDFDefect-Induced Electron Localization Promotes DO Dissociation and Nitrile Adsorption for Deuterated Amines.
Angew Chem Int Ed Engl
January 2025
Department of Chemistry, School of Science, Tianjin University, Tianjin, 300072, China.
Electrochemical reductive deuteration of nitriles is a promising strategy for synthesizing deuterated amines with DO as the deuterated source. However, this reaction suffers from high overpotentials owing to the sluggish DO dissociation kinetics and high thermodynamic stability of the C≡N triple bond. Here, low-coordinated copper (LC-Cu) is designed to decrease the overpotential for the electrosynthesis of the precursor of Melatonin-d, 5-methoxytryptamine-d, by 100 mV with a 68 % yield (Faradaic efficiency), which is 4 times greater than that of high-coordinated copper (HC-Cu).
View Article and Find Full Text PDFMicrobial melatonin metabolism in the human intestine as a therapeutic target for dysbiosis and rhythm disorders.
NPJ Biofilms Microbiomes
November 2024
Laboratory of Food Systems Biotechnology, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
Melatonin (MT) (N-acetyl-5-methoxytryptamine) is an indoleamine recognized primarily for its crucial role in regulating sleep through circadian rhythm modulation in humans and animals. Beyond its association with the pineal gland, it is synthesized in various tissues, functioning as a hormone, tissue factor, autocoid, paracoid, and antioxidant, impacting multiple organ systems, including the gut-brain axis. However, the mechanisms of extra-pineal MT production and its role in microbiota-host interactions remain less understood.
View Article and Find Full Text PDFTryptophan Metabolites in the Progression of Liver Diseases.
Biomolecules
November 2024
Department of Internal Medicine, Gastroenterology and Hepatology, I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia.
The aim of this study was to investigate the levels of various tryptophan metabolites in patients with alcoholic liver disease (ALD) and metabolic-associated fatty liver disease (MAFLD) at different stages of the disease. The present study included 44 patients diagnosed with MAFLD, 40 patients diagnosed with ALD, and 14 healthy individuals in the control group. The levels of tryptophan and its 16 metabolites (3-OH anthranilic acid, 5-hydroxytryptophan, 5-methoxytryptamine, 6-hydroxymelatonin, indole-3-acetic acid, indole-3-butyric, indole-3-carboxaldehyde, indole-3-lactic acid, indole-3-propionic acid, kynurenic acid, kynurenine, melatonin, quinolinic acid, serotonin, tryptamine, and xanthurenic acid) in the serum were determined via high-performance liquid chromatography and tandem mass spectrometry.
View Article and Find Full Text PDFMelatonin as an adjunctive therapy in cardiovascular disease management.
Sci Prog
November 2024
Department of Cardiovascular Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Clinical Medicine, Hangzhou, China.
Melatonin, N-acetyl-5-methoxytryptamine, is a neuroendocrine hormone secreted by the pineal gland. This pleiotropic indoleamine possesses amphiphilic properties, allowing it to penetrate most biological barriers and exert its effects at the subcellular level. Importantly, melatonin also plays a crucial role in regulating the body's response to circadian rhythms, adapting to internal and external environmental cues.
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