Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Milk Fat Globules: 2024 Updates.
Newborn (Clarksville)
March 2024
Global Newborn Society, Clarksville Maryland, United States of America.
Article Synopsis
- * MFGs feature a unique structure with a lipid core and a membrane rich in bioactive components that aid in energy release and support immune health in developing gastrointestinal tracts.
- * Research suggests MFGs can be enhanced to address specific nutritional deficiencies while also having potential therapeutic benefits for neurodevelopment and defense against infections.
NEIL3 promotes cell proliferation of ccRCC via the cyclin D1-Rb-E2F1 feedback loop regulation.
DNA Repair (Amst)
January 2024
Department of Urology, the First Affiliated Hospital of Xi'an Jiaotong University, China; Oncology Research Lab, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, #277 Yanta West Road, Xi'an 710061, China. Electronic address:
Article Synopsis
- - NEIL3 is a new gene linked to tumors, and it's found to be more active in a type of kidney cancer called clear cell renal cell carcinoma (ccRCC).
- - Researchers discovered that NEIL3 helps cancer cells grow and multiply by interacting with other proteins in a process known as a feedback loop.
- - The study showed that patients with higher levels of NEIL3 in their tumors had more severe cancer, suggesting it could be useful for diagnosing and treating ccRCC.
[Overexpression of Nei endonuclease VIII-like protein 3 in hepatocellular carcinoma indicates increased levels of immune infiltration and an unfavorable prognosis].
Zhonghua Gan Zang Bing Za Zhi
September 2023
Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, China.
To evaluate the role and molecular mechanism of Nei endonuclease VIII-like protein 3 (NEIL3) in hepatocellular carcinoma (HCC) through The Cancer Genome Atlas database. RNA sequencing of HCC samples was the first step in determining the level of gene NEIL3 expression in normal tissues and tumors. Then, NEIL3 was used for the Gene Ontology, the Kyoto Encyclopedia of Genes and Genomes, gene enrichment analysis, immune cell infiltration analysis.
View Article and Find Full Text PDFEndonuclease VIII-like 1 deficiency potentiates nigrostriatal dopaminergic neuron degeneration in a male mouse model of Parkinson's disease.
J Neurochem
June 2023
Department of Physiology, National Cheng Kung University, Tainan, Taiwan.
Parkinson's disease (PD) is a common movement disorder caused by a characteristic loss of dopaminergic neurons in the substantia nigra and degeneration of dopamine terminals in the dorsal striatum. Previous studies have suggested that oxidative stress-induced DNA damage may be involved in PD pathogenesis, as steady-state levels of several types of oxidized nucleobases were shown to be elevated in PD brain tissues. These DNA lesions are normally removed from the genome by base excision repair, which is initiated by DNA glycosylase enzymes such as endonuclease VIII-like 1 (Neil1).
View Article and Find Full Text PDFInvestigation of base excision repair gene variants in late-onset Alzheimer's disease.
PLoS One
March 2020
Department of Molecular Biology and Genetics.
Base excision repair (BER) defects and concomitant oxidative DNA damage accumulation play a role in the etiology and progression of late-onset Alzheimer's disease (LOAD). However, it is not known whether genetic variant(s) of specific BER genes contribute to reduced BER activity in LOAD patients and whether they are associated with risk, development and/or progression of LOAD. Therefore, we performed targeted next generation sequencing for three BER genes, uracil glycosylase (UNG), endonuclease VIII-like DNA glycosylase 1 (NEIL1) and polymerase β (POLβ) including promoter, exonic and intronic regions in peripheral blood samples and postmortem brain tissues (temporal cortex, TC and cerebellum, CE) from LOAD patients, high-pathology control and cognitively normal age-matched controls.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!