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Overlapping and differential neuropharmacological mechanisms of stimulants and nonstimulants for attention-deficit/hyperactivity disorder: a comparative neuroimaging analysis.
Psychol Med
January 2025
Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Functional & Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China.
Background: Psychostimulants and nonstimulants have partially overlapping pharmacological targets on attention-deficit/hyperactivity disorder (ADHD), but whether their neuroimaging underpinnings differ is elusive. We aimed to identify overlapping and medication-specific brain functional mechanisms of psychostimulants and nonstimulants on ADHD.
Methods: After a systematic literature search and database construction, the imputed maps of separate and pooled neuropharmacological mechanisms were meta-analyzed by Seed-based Mapping toolbox, followed by large-scale network analysis to uncover potential coactivation patterns and meta-regression analysis to examine the modulatory effects of age and sex.
Neuropharmacological potential of Mimosa tenuiflora in adult zebrafish: An integrated approach to GABAergic and serotonergic neuromodulation.
Behav Brain Res
January 2025
Experimental Biology Center, University of Fortaleza, Av. Washington Soares, 1321 - Fortaleza, Ceará, Brazil. Electronic address:
Mimosa tenuiflora ("jurema-preta") is traditionally used in folk medicine for various diseases. The study investigated the neuropharmacological potential of Mimosa tenuiflora bark fraction (FATEM) in adult zebrafish. This included the acute toxicity (LC50) of FATEM (0.
View Article and Find Full Text PDFGC-MS Analysis, Neuropharmacological, and Antidiarrheal Activities of the Acetone Extract of Najas gracillima Seaweed: In Vivo and In Silico Study.
Chem Biodivers
December 2024
De, partment of Pharmacy, Faculty of Biological Sciences, University of Chittagong, Chittagong, Bangladesh.
Najas gracillima, a marine seaweed found in North America and Asia, was investigated for its neuropharmacological and antidiarrheal properties. Acetone extracts of N. gracillima (ANG) were analyzed using both in vivo and in silico methods.
View Article and Find Full Text PDFA comprehensive analysis of propofol abuse and addiction and neuropharmacological aspects: an updated review.
Korean J Anesthesiol
December 2024
Department of Medical Pharmacology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpaşa, İstanbul, Turkey.
This review aims to assess the existing studies on propofol, a relatively new intravenous anesthetic, related to its abuse and addictive potential and to explain the neurobiological and neuropharmacological aspects of propofol addiction. Several neurobiological factors related to complex processes in the brain influence propofol abuse and addiction. In this review, we assessed the literature regarding propofol abuse and addiction, including both experimental and clinical studies.
View Article and Find Full Text PDFHarnessing the spatial and transcriptional regulation of monoterpenoid indole alkaloid metabolism in Alstonia scholaris leads to the identification of broad geissoschizine cyclase activities.
Plant Physiol Biochem
November 2024
Biomolécules et Biotechnologies Végétales, EA2106, Université de Tours, 37200, Tours, France. Electronic address:
Monoterpene indole alkaloids (MIAs) are valuable metabolites produced in numerous medicinal plants from the Apocynaceae family such as Alstonia scholaris, which synthesizes strictamine, a MIA displaying neuropharmacological properties of a potential importance. To get insights into the MIA metabolism in A. scholaris, we studied here both the spatial and transcriptional regulations of MIA genes by performing a robust transcriptomics analysis of the main plant organs, leaf epidermis but also by sequencing RNA from leaves transiently overexpressing the master transcriptional regulator MYC2.
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