AI Article Synopsis
- The study aimed to analyze immune activation markers soluble ICAM-1 and soluble IL-2R in patients with active uveitis.
- Levels of these markers were measured in both the aqueous humor (fluid in the eye) and peripheral blood of 23 uveitis patients and 16 control subjects.
- Results showed elevated levels of both markers in uveitis patients, indicating their potential role in the disease's local and systemic processes.
Article Abstract
Purpose: To study the ocular and systemic behaviour of the immune activation markers soluble ICAM-1 and soluble IL-2R in patients with active uveitis.
Methods: We determined the levels of soluble ICAM-1 and soluble IL-2R in the aqueous humor and peripheral blood of 23 patients with active uveitis and 16 age and gender matched controls (who were to undergo cataract extraction) by means of ELISA enzyme immunoanalysis.
Results: Patients with uveitis presented higher levels of soluble ICAM-1 and soluble IL-2R in the aqueous humor and peripheral blood. Comparison of the aqueous humor and peripheral blood revealed higher levels of soluble ICAM-1 in the aqueous humor, while we found no differences for soluble IL-2R. Analysis of the clinical characteristics of the uveitis we studied showed no differences in the levels of these markers in either blood or aqueous humor.
Conclusions: The finding of elevated levels of soluble IL-2R and soluble ICAM-1 in the aqueous humor and peripheral blood of patients with uveitis suggests the local and systemic participation of these markers in the pathogenesis of uveitis.
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