A new cryosurgical device was developed in an attempt to overcome problems of current systems. It incorporates a mixed-fluid J-T stage, thereby reducing working pressure. This allows incorporation of an oil-free compressor to circulate the mixture and eliminates the need for coolant replenishment. The compressor console is small and portable, with a footprint of 3.5 square feet. Probe surface temperatures of -90 to -110 inverted exclamation mark C are achieved. Working pressures are reduced 3- to 10-fold over existing devices (300-350 p.s.i.). In a live goat study, liver ice balls 3.7 cm in diameter were created in 10 minutes. In an extirpated uterus, in a 37 inverted exclamation mark C water bath, tissue ice balls ranging from 29.1 to 35.4 mm were created in 6 minutes and tissue was destroyed to depths of 6 to 12 mm. This cryosurgical system is suitable for endometrial ablation.
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http://dx.doi.org/10.1016/s1074-3804(00)80049-3 | DOI Listing |
The right trisectionectomy is the main treatment modality for locally advanced gallbladder cancer with invasion of the intraparenchymal portal vein branches because it allows the achievement of negative resection margins (R0). However, only 10%-25% of such patients are eligible for surgery. The cryosurgical method has been successfully used in the complex treatment of hepatopancreatobiliary malignant neoplasms for many years.
View Article and Find Full Text PDFJ Otolaryngol Head Neck Surg
April 2023
Department of Otolaryngology - Head and Neck Surgery, University of Toronto, Toronto, ON, Canada.
Background: ClariFix is a novel intranasal cryotherapy device developed for clinic-based cryosurgical ablation of the posterior nasal nerves region. As a relatively new technology, there is a paucity of studies within the literature assessing the efficacy and safety profile of ClariFix for chronic rhinitis.
Methods: A systematic review was completed in accordance with PRISMA guidelines.
Allergy Rhinol (Providence)
January 2021
Department of Otolaryngology Head and Neck Surgery, Kaiser Permanente, Orange County, California.
Background: Chronic rhinitis is a common condition generally treated with medical therapies. However, 10-22% of patients are refractory to medical therapies. A cryotherapy handheld device targeting the postganglionic nerve fibers of the posterior nasal nerve (PNN) now serves as an additional option for therapy.
View Article and Find Full Text PDFOtolaryngol Head Neck Surg
October 2021
Division of Otolaryngology, Yale University School of Medicine, New Haven, Connecticut, USA.
Posterior nasal nerve (PNN) cryoablation is a novel surgical technique used to address chronic rhinitis. The purpose of this study is to review the medical device reports (MDRs) submitted to the Food and Drug Administration's (FDA) Manufacturer and User Device Facility Experience (MAUDE) database to identify adverse events related to the use of ClariFix, a device designed for office-based cryosurgical ablation of the PNN. A total of 12 adverse events associated with ClariFix from January 2017 to August 2020 were identified and analyzed.
View Article and Find Full Text PDFAnn Thorac Surg
August 2021
Division of Cardiac Surgery, Feinberg School of Medicine and the Bluhm Cardiovascular Institute, Northwestern University, Chicago, Illinois.
Background: Although cryosurgery has been used to treat cardiac arrhythmias for nearly 5 decades, the mechanism of action and the surgical technique that produces optimal cryolesions for the treatment of atrial fibrillation are still poorly understood. This has resulted in surgical outcomes that can be improved by a better understanding the mechanisms of cryothermia ablation and the proper surgical techniques that take advantage of those mechanisms.
Methods: The cryobiology underlying cryosurgical ablation is described, as are the nuances of cryosurgical techniques that ensure the reliable creation of contiguous, uniformly transmural atrial cryolesions.
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