AI Article Synopsis
- A numerical simulator was created to analyze how voltage spreads in vestibular macular afferents, using a method similar to computational fluid dynamics.
- Different configurations of synapses and their activation timing were tested to observe their effects on discharge properties and latency.
- The findings suggest that the way synapses are activated and the structure of the neuron influence how voltage spreads and how quickly signals are transmitted, with potential applications for studying more complex neuron types in future research.
Article Abstract
A quasi-three-dimensional finite-volume numerical simulator was developed to study passive voltage spread in vestibular macular afferents. The method, borrowed from computational fluid dynamics, discretizes events transpiring in small volumes over time. The afferent simulated had three calyces with processes. The number of processes and synapses, and direction and timing of synapse activation, were varied. Simultaneous synapse activation resulted in shortest latency, while directional activation (proximal to distal and distal to proximal) yielded most regular discharges. Color-coded visualizations showed that the simulator discretized events and demonstrated that discharge produced a distal spread of voltage from the spike initiator into the ending. The simulations indicate that directional input, morphology, and timing of synapse activation can affect discharge properties, as must also distal spread of voltage from the spike initiator. The finite volume method has generality and can be applied to more complex neurons to explore discrete synaptic effects in four dimensions.
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| http://dx.doi.org/10.1023/a:1008976030745 | DOI Listing |
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