AI Article Synopsis
- The study evaluated the pain relief and side effects of clonidine compared to a placebo in patients undergoing hemorrhoid surgery.
- Patients were divided into two groups: one received clonidine with a local anesthetic, while the other received a saline solution.
- Results showed that those receiving clonidine had a significantly longer time before needing additional pain relief, but some experienced bradycardia without changes in blood pressure.
Article Abstract
We have assessed the analgesic efficacy and side effects of caudally administered clonidine in a prospective, randomized, double-blind, placebo-controlled study. We studied 64 adult patients undergoing elective haemorrhoidectomy. Caudal block was performed in all patients using a mixture of 0.5% bupivacaine 35 mg with 2% lidocaine 140 mg and epinephrine 5 micrograms ml-1. Patients were allocated randomly to one of two groups. Clonidine 75 micrograms was added in group C and saline 1 ml in group S. Median time to first analgesic requirements was significantly longer in group C (mean 729 (SD 120) min) than in group S (276 (131) min) (P = 0.01). Bradycardia occurred in seven patients in group C but did not affect mean arterial pressure.
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| http://dx.doi.org/10.1093/oxfordjournals.bja.a013448 | DOI Listing |
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