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Collagenous Spherulosis Presenting as Architectural Distortion on Mammography.
J Breast Imaging
May 2024
Department of Radiology, University of Missouri - Kansas City School of Medicine, Kansas City, MO, USA.
Overcoming Pitfalls in Breast Fine-Needle Aspiration Cytology: A Practical Review.
Acta Cytol
August 2024
IPATIMUP-Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal.
Background: Fine-needle aspiration cytology (FNAC) is a cornerstone technique for the initial assessment of breast lesions, offering a rapid and minimally invasive option for cytological evaluation. While FNACs can forego the need for core needle biopsies (CNBs), variations in technique, subjective interpretation, and intrinsic limitations present diagnostic challenges. The International Academy of Cytology (IAC) established the Yokohama system and is developing the WHO Reporting System for Breast Cytopathology jointly with IARC, to standardize diagnostic criteria, aiming to enhance diagnostic precision and consistency.
View Article and Find Full Text PDFImmunohistochemical marker profiles for the differentiation of collagenous spherulosis from adenoid cystic carcinoma of the breast.
Hum Pathol
June 2024
Institute of Pathology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. Electronic address:
Collagenous spherulosis (CS) is a rare breast lesion of unknown histogenesis. Adenoid cystic carcinoma (ACC) is a rare basal-like breast carcinoma with low histological grade. CS is a benign lesion but resembles ACC.
View Article and Find Full Text PDFUsual breast lump with unusual features.
Cytopathology
March 2024
Department of General Surgery, All India Institute of Medical Sciences, Raebareli, India.
The co-existence of granulomatous mastitis and collagenous spherulosis in a breast lump is an uncommon finding. The awareness of cytomorphological features can help corroborate a cytological diagnosis. A palpable breast lump in an elderly female warrants urgent attention and fine needle aspiration is a rapid, reliable method of evaluation.
View Article and Find Full Text PDFMYB RNA In Situ Hybridization Is a Useful Diagnostic Tool to Distinguish Breast Adenoid Cystic Carcinoma From Other Triple-negative Breast Carcinomas.
Am J Surg Pathol
July 2022
Departments of Pathology.
Article Synopsis
- Breast adenoid cystic carcinoma (AdCC) shares similarities with basal-like triple-negative breast carcinoma (TNBC) but has a better prognosis, making precise diagnosis important.
- A new method, MYB RNA in situ hybridization (ISH), is highlighted for its effectiveness in identifying AdCC and shows promise for use in other breast cancer types.
- The study found that MYB RNA ISH overexpression is common in AdCC but rare in TNBC, suggesting that this test could aid in distinguishing between these types of breast cancer.
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