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Recruitment and Differential Firing Patterns of Single Units During Conditioning to a Tone in a Mute Locked-In Human.
Front Hum Neurosci
September 2022
Belize International Institute of Neuroscience, Belize City, Belize.
Single units that are not related to the desired task can become related to the task by conditioning their firing rates. We theorized that, during conditioning of firing rates to a tone, (a) unrelated single units would be recruited to the task; (b) the recruitment would depend on the phase of the task; (c) tones of different frequencies would produce different patterns of single unit recruitment. In our mute locked-in participant, we conditioned single units using tones of different frequencies emitted from a tone generator.
View Article and Find Full Text PDFSlow Firing Single Units Are Essential for Optimal Decoding of Silent Speech.
Front Hum Neurosci
August 2022
Neural Signals Inc., Neural Prostheses Laboratory, Duluth, GA, United States.
The motivation of someone who is locked-in, that is, paralyzed and mute, is to find relief for their loss of function. The data presented in this report is part of an attempt to restore one of those lost functions, namely, speech. An essential feature of the development of a speech prosthesis is optimal decoding of patterns of recorded neural signals during speech, that is, speaking "inside the head" with output that is inaudible due to the paralysis of the articulators.
View Article and Find Full Text PDFPerformance Characteristics of a Novel 3D-Printed Bubble Intermittent Mandatory Ventilator (B-IMV) for Adult Pulmonary Support.
Bioengineering (Basel)
April 2022
Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.
The COVID-19 pandemic has brought attention to the need for developing effective respiratory support that can be rapidly implemented during critical surge capacity scenarios in healthcare settings. Lung support with bubble continuous positive airway pressure (B-CPAP) is a well-established therapeutic approach for supporting neonatal patients. However, the effectiveness of B-CPAP in larger pediatric and adult patients has not been addressed.
View Article and Find Full Text PDFHistological Confirmation of Myelinated Neural Filaments Within the Tip of the Neurotrophic Electrode After a Decade of Neural Recordings.
Front Hum Neurosci
April 2020
Neural Signals Inc., Duluth, GA, United States.
Aim: Electrodes that provide brain to machine or computer interfacing must survive the lifetime of the person to be considered an acceptable prosthetic. The electrodes may be external such as with electroencephalographic (EEG), internal extracortical such as electrocorticographic (ECoG) or intracortical.
Methods: Most intracortical electrodes are placed close to the neuropil being recorded and do not survive years of recording.
Emphysematous cholecystitis following routine colonoscopy.
J Surg Case Rep
April 2020
Department of Surgery, Tamworth Rural and Referral Hospital, Tamworth, New South Wales, Australia.
Cholecystitis is a rare sequela of colonoscopy, the relationship between which has not yet been defined. This case study reviews a rural elderly patient who developed right upper quadrant pain following routine colonoscopy. He developed emphysematous cholecystitis, which required laparoscopy with conversion to open via Kocher's incision and underwent a subtotal cholecystectomy due to the severity of necrosis and inflammation.
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