A new class of glutathione transferases has been discovered by analysis of the expressed sequence tag data base and sequence alignment. Glutathione S-transferases (GSTs) of the new class, named Omega, exist in several mammalian species and Caenorhabditis elegans. In humans, GSTO 1-1 is expressed in most tissues and exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities characteristic of the glutaredoxins. The structure of GSTO 1-1 has been determined at 2.0-A resolution and has a characteristic GST fold (Protein Data Bank entry code ). The Omega class GSTs exhibit an unusual N-terminal extension that abuts the C terminus to form a novel structural unit. Unlike other mammalian GSTs, GSTO 1-1 appears to have an active site cysteine that can form a disulfide bond with glutathione.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1074/jbc.M001706200 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Lactococcus lactis subsp. Lactis boosts stress resistance and host defense mechanisms in Caenorhabditis elegans.
J Appl Microbiol
January 2025
Graduate School of Human Life and Ecology, Osaka Metropolitan University, 3-3-138, Sugimoto, Sumiyoshi-Ku, Osaka 558-8585, Japan.
Aims: To investigate the effects of Lactococcus lactis subsp. lactis strains LL100933 and LL12007 on the host defense mechanisms of Caenorhabditis elegans against pathogenic infections and stressors.
Methods And Results: C.
Gene transcription in the oyster Crassostrea gigas exposed to environmental concentrations of the UV filter Benzophenone-3.
Aquat Toxicol
January 2025
Laboratory of Biomarkers of Aquatic Contamination and Immunochemistry-LABCAI, Federal University of Santa Catarina - UFSC, Florianópolis, SC 88037-000, Brazil. Electronic address:
Personal care products (PCPs), such as sunscreens, are usually found in various aquatic ecosystems at low concentrations (ng l to µg l). However, there is limited information regarding their effects on marine bivalves. Therefore, the aim of this study was to evaluate the sublethal effects of environmental concentrations (1 and 100 µg l) of benzophenone-3 (BP-3) in Crassostrea gigas oysters after 1 and 7 days of exposure.
View Article and Find Full Text PDFExperimental assessment of ozone risk on ecotypes of the tropical tree Moringa oleifera.
Environ Res
October 2021
Department of Agriculture, Environment, Food, and Forestry, University of Florence, Viale Delle Idee, 30, 50019, Sesto Fiorentino, Italy; Institute for Sustainable Plant Protection (IPSP), National Research Council (CNR), Via Madonna Del Piano 10, 50019, Sesto Fiorentino, Italy.
Ozone (O) is an oxidative air pollutant that affects plant growth. Moringa oleifera is a tree species distributed in the tropical and subtropical regions. This species presents high morphological plasticity, which increases its ability to tolerate stressful conditions, but with no O risk assessment calculated so far.
View Article and Find Full Text PDFGlutathione peroxidase-2 protects from allergen-induced airway inflammation in mice.
Eur Respir J
May 2010
Dept of Paediatric Pneumology and Immunology, Charité Humboldt University, Germany.
The aim of the present study was to identify and validate the biological significance of new genes/proteins involved in the development of allergic airway disease in a murine asthma model. Gene microarrays were used to identify genes with at least a two-fold increase in gene expression in lungs of two separate mouse strains with high and low allergic susceptibility. Validation of mRNA data was obtained by western blotting and immunohistochemistry, followed by functional analysis of one of the identified genes in mice with targeted disruption of specific gene expression.
View Article and Find Full Text PDFCloning, expression and characterization of human glutathione S-transferase Omega 2.
Int J Mol Med
July 2005
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, PR China.
The class of Omega glutathione transferases is newly identified with novel structural and functional characteristics. Human GSTO 1-1 (glutathione S-transferase Omega 1) is the first member of the GST Omega class. It was found to play a role in apoptosis and be in association with age-at-onset of AD and PD.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!