Synthesis and antimicrobial activity of 1,4-diaryl-2-azetidinones.

Farmaco

Department of Chemistry, Faculty of Science, Hacettepe University, Ankara, Turkey.

Published: February 2000

Cycloaddition of substituted 4,4-benzylidene-anilines to in situ prepared dichloroketenes in the presence of dichloroacetyl chloride and triethylamine affords a variety of 2-azetidinones. All the compounds were characterized by IR and 1H NMR. Their antimicrobial activity, against Gram(+) and Gram(-) bacteria and fungi, was tested.

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0014-827x(99)00126-3DOI Listing

Publication Analysis

Top Keywords

antimicrobial activity
8
synthesis antimicrobial
4
activity 14-diaryl-2-azetidinones
4
14-diaryl-2-azetidinones cycloaddition
4
cycloaddition substituted
4
substituted 44-benzylidene-anilines
4
44-benzylidene-anilines situ
4
situ prepared
4
prepared dichloroketenes
4
dichloroketenes presence
4

Similar Publications

Methicillin-resistant (MRSA) causes osteomyelitis (OM), which seriously threatens public health due to its antimicrobial resistance. To increase the sensitivity of antibiotics and eradicate intracellular bacteria, a Zn and vancomycin (Van) codelivered nanotherapeutic (named Man-Zn/Van NPs) was fabricated and characterized via mannose (Man) modification. Man-Zn/Van NPs exhibit significant inhibitory activity against extra- and intracellular MRSA and obviously decrease the minimum inhibitory concentration of Van.

View Article and Find Full Text PDF

The use of adjunct chemical substances in the early postoperative period of periodontal surgical procedures is recommended due to the potential risk of trauma in the operated area. Chlorhexidine digluconate mouthwash is widely used but can cause adverse effects. Phthalocyanine derivatives are being studied as an alternative, demonstrating good antimicrobial activity, especially in the self-activated form, which does not require additional light or chemicals.

View Article and Find Full Text PDF

Objective: Heavy metal pollution is one of the more recent problems of environmental degradation caused by rapid industrialization and human activity. The objective of this study was to isolate, screen, and characterize heavy metal-resistant bacteria from solid waste disposal sites.

Methods: In this study, a total of 18 soil samples were randomly selected from mechanical sites, metal workshops, and agricultural land that received wastewater irrigation.

View Article and Find Full Text PDF

MXenes are a class of 2D transition metal carbides and nitrides (MXT) that have attracted significant interest owing to their remarkable potential in various fields. The unique combination of their excellent electromagnetic, optical, mechanical, and physical properties have extended their applications to the biological realm as well. In particular, their ultra-thin layered structure holds specific promise for diverse biomedical applications.

View Article and Find Full Text PDF

Background: In continuation of our chemical and biological work on Tithonia tubaeformis, we evaluated the antipyretic activity of its extract which on fractionation gives a pure alkaloid galegine. Galegine a bioprivileged compound, is a hemiterpene bearing a guanidine group, which holds significant importance in medicinal chemistry. Biological activities such as antimicrobial, antidiabetic, anti-inflammatory, cardiovascular, anticancer, and antihypertensive, are often associated with guanidine-containing molecules.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!