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Association of vitamin D receptor gene polymorphisms, metabolic features and susceptibility to polycystic ovary syndrome: a preliminary study.
Reprod Biomed Online
September 2024
UMF Iuliu Haţieganu, Cluj-Napoca, Romania.
Research Question: Are the combined genotypes and haplotypes of vitamin D receptor (VDR) gene polymorphisms (FokI, ApaI and TaqI) associated with susceptibility to polycystic ovary syndrome (PCOS) and metabolic features of the disease?
Design: This case-control study included 46 women with PCOS and 48 controls. Genotypes of the VDR gene were determined using the polymerase chain reaction-restriction fragment length polymorphism method. Waist circumference, and parameters of lipid and glucose metabolism were evaluated in all women.
The vitamin D receptor TaqI TT genotype is associated with type 1 diabetes in the Black South African population.
J Nutr Sci
December 2024
Department of Chemical Pathology, National Health Laboratory Services (NHLS), Johannesburg, South Africa.
Polymorphisms in the vitamin D receptor (VDR) gene (BsmI (rs1544410), FokI (rs2228570), ApaI (rs7975232), TaqI (rs731236)) and low vitamin D concentrations have previously been associated with type 1 diabetes (T1D). Vitamin D is thought to mediate the switch from a pro-inflammatory Th1 response to an anti-inflammatory Th2 response which is protective against the development of T1D. These associations are inconsistent across studies and population groups.
View Article and Find Full Text PDFPolymorphism in the Vitamin D Receptor Gene Decreases the Risk of Perianal Fistulas in Crohn's Disease.
Nutrients
October 2024
Departamento de Farmacología and CIBERehd, Facultad de Medicina, Universidad de Valencia, Av. Blasco Ibáñez, 15, 46010 Valencia, Spain.
Background: Vitamin D, through the activation of its receptor (VDR), plays an immunomodulatory role in the gastrointestinal tract. Single-nucleotide polymorphisms (SNPs) in the VDR gene have been associated with Crohn's disease (CD) risk, and patients carrying the polymorphism in this gene run a higher risk of developing a penetrating behavior.
Aims: We analyzed the association of , , , and SNPs in the gene with the clinical characteristics of CD.
Prevalence and molecular identification of hypodermosis from slaughtered cattle in Sulaymaniyah province, Iraq.
J Infect Dev Ctries
August 2024
College of Health and Medical Technology, Sulaimani Polytechnic University, Sulaymaniyah, Iraq.
Introduction: Hypodermosis is a subcutaneous infestation in cattle that is caused by larvae of Hypoderma spp. and it is an economically important disease in the cattle industry. This study aimed to find the prevalence rate of hypodermosis and identify variations in the COX1 gene among isolates present in Sulaymaniyah, in the Kurdistan region of Iraq.
View Article and Find Full Text PDFMolecular investigation of vitamin D receptor (VDR) genetic variants and their impact on VDR mRNA and serum vitamin D levels in allergic rhinitis in an Indian population: A case-control study.
Int J Immunogenet
October 2024
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Article Synopsis
- Vitamin D deficiency is common and linked to allergic diseases due to its role in immune regulation; the study focuses on the role of vitamin D receptor (VDR) genetic variants in allergic rhinitis (AR).
- Research examined three specific VDR variants (TaqI, FokI, and BsmI) among 550 participants, finding that FokI and BsmI variants are associated with higher susceptibility to AR.
- The study revealed that AR patients had significantly lower VDR mRNA and serum vitamin D levels, indicating a complex relationship between VDR genetic variations and immune response in allergic conditions.
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