The diversity of strategies reflects as much the lack of ideal treatments as it does the imagination of the investigators. Many aspects such as manipulation of apoptosis and extracorporeal removal of autoantibodies have been omitted due to space restrictions. Although most successful treatment strategies have been based on proven basic research principles, most require well performed, prospective, randomised clinical trials before optimistic anecdotes translate to clinical practice. We must not forget the aim of improving quality of life for our patients, and not just improvement of immunological laboratory parameters.
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