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Identification and Validation of Serum Biomarkers to Improve Colorectal Cancer Diagnosis.
Cancer Med
December 2024
Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Article Synopsis
- The study addresses the urgent need for reliable biomarkers in colorectal cancer (CRC) diagnosis, highlighting limitations in current methods and the potential for novel, non-invasive solutions.
- Using advanced genomic and proteomic technologies, researchers identified five promising biomarkers: INHBA, MMP7, PSAT1, SLC7A5, and TGFBI, which showed significantly higher expression levels in CRC patients compared to healthy controls.
- The biomarkers demonstrated strong diagnostic accuracy, with AUC values between 0.8361 and 0.9869, suggesting they could greatly improve early detection and precision in CRC diagnostic practices.
Activins and Inhibins in Cardiovascular Pathophysiology.
Biomolecules
November 2024
Department of Cardiology, The First Hospital of China Medical University, Shenyang 110001, China.
Activins and inhibins, members of the transforming growth factor β (TGFβ) superfamily, were initially recognized for their opposing effects on the secretion of follicle-stimulating hormone. Subsequent research has demonstrated their broader biological roles across various tissue types. Primarily, activins and inhibins function through the classical TGFβ SMAD signaling pathway, but studies suggest that they also act through other pathways, with their specific signaling being complex and context-dependent.
View Article and Find Full Text PDFDNA hypomethylation of INHBA promotes tumor progression and predicts prognosis and immune status of gastric cancer.
Hereditas
November 2024
Department of Gastroenterology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Objective: Gastric cancer (GC) is characterized by its high malignancy and poor prognosis. However, the role of Inhibin subunit beta A (INHBA) in GC remains insufficiently understood. This study aims to comprehensively evaluate the clinical significance, biological roles, and possible mechanisms of INHBA in GC.
View Article and Find Full Text PDFThe impact of weight loss on fat-free mass, muscle, bone and hematopoiesis health: Implications for emerging pharmacotherapies aiming at fat reduction and lean mass preservation.
Metabolism
December 2024
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Section of Endocrinology, Boston VA Healthcare System, Harvard Medical School, Boston, MA, USA. Electronic address:
Similar to bariatric surgery, incretin receptor agonists have revolutionized the treatment of obesity, achieving up to 15-25 % weight loss in many patients, i.e., at a rate approaching that achieved with bariatric surgery.
View Article and Find Full Text PDFMolecular mechanisms and clinicopathological characteristics of inhibin βA in thyroid cancer metastasis.
Int J Mol Med
November 2024
Department of Otolaryngology‑Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong 250022, P.R. China.
The present study aimed to investigate the role and mechanism of inhibin βA (INHBA) in thyroid cancer (TC), and to determine its potential impact on the aggressive behavior of TC cells. The present study employed a comprehensive approach, using public databases, such as the Gene Expression Omnibus and The Cancer Genome Atlas, to identify and analyze the expression of INHBA in TC. Cell transfection, reverse transcription‑quantitative PCR, western blot analysis, immunohistochemistry and assays were conducted to investigate the functional effects of INHBA on TC.
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