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Anticancer Properties of Phenylboronic Acid in Androgen-Dependent (LNCaP) and Androgen-Independent (PC3) Prostate Cancer Cells via MAP Kinases by 2D and 3D Culture Methods.
Anticancer Agents Med Chem
January 2025
Department of Histology and Embryology, Faculty of Medicine, Istanbul Medipol University, Istanbul, Türkiye.
Objective: This study utilized three cell lines: normal prostate epithelial RWPE-1, androgen-dependent LNCaP, and androgen-independent PC3. We investigated the inhibitory effects of phenylboronic acid (PBA)'s inhibitory effect on cellular proliferation due to its ability to disrupt microtubule formation in prostate cancer cell lines. Additionally, this study aimed to assess the cytotoxic effects of PBA on prostate cancer cells using twodimensional (2D) and three-dimensional (3D) cell culture models.
View Article and Find Full Text PDFWKB ameliorates DSS-induced colitis through inhibiting enteric glial cells activation and altering the intestinal microbiota.
J Transl Med
January 2025
Department of Gastroenterology, Air Force Medical Center, No. 30 Fucheng Road, Haidian District, Beijing, 100142, China.
Background: Inflammatory bowel disease (IBD) is a chronic condition influenced by diet, which affects gut microbiota and immune functions. The rising prevalence of IBD, linked to Western diets in developing countries, highlights the need for dietary interventions. This study aimed to assess the impact of white kidney beans (WKB) on gut inflammation and microbiota changes, focusing on their effects on enteric glial cells (EGCs) and immune activity in colitis.
View Article and Find Full Text PDFA Case Report of an Immature Pituitary-Specific Transcription Factor 1 (PIT1)-Lineage Pituitary Neuroendocrine Tumor Along With Its Cytology and Ultrastructural Studies.
Cureus
December 2024
Department of Pathology, Section of Oncopathology and Morphological Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, JPN.
Immature pituitary-specific transcription factor 1 (PIT1)-lineage pituitary neuroendocrine tumors are composed of PIT1-lineage cells with cytological atypia and limited differentiation. These tumors are rare and no cytological features of this neoplasm have been reported. This study is the first to report the cytological features of an immature PIT1-lineage tumor.
View Article and Find Full Text PDFEpithelial OPA1 links mitochondrial fusion to inflammatory bowel disease.
Sci Transl Med
January 2025
Department of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, 91052 Erlangen, Germany.
Dysregulation at the intestinal epithelial barrier is a driver of inflammatory bowel disease (IBD). However, the molecular mechanisms of barrier failure are not well understood. Here, we demonstrate dysregulated mitochondrial fusion in intestinal epithelial cells (IECs) of patients with IBD and show that impaired fusion is sufficient to drive chronic intestinal inflammation.
View Article and Find Full Text PDFInsights into morphology of the 'columnar epithelium' within the female reproductive system of brachyuran crabs.
Arthropod Struct Dev
January 2025
Zoological Museum, University of Kiel, Hegewischstrasse 3, 24105, Kiel, Germany.
The objective of this study is to gain a better understanding of the not well understood egg-transportation mechanisms through the female reproductive systems of crabs. For this, Carcinus maenas was chosen as a model to study the cuticular epithelium underlying the cuticle of the vagina and the ventral seminal receptacle. This cuticular epithelium is investigated by performing histochemical and ultrastructural analyses of the epithelial cells.
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