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Recurrence of complex regional pain syndrome after administration of adenosine.
Pain Manag
May 2019
Department of Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
The effects of adenosine in acute chronic pain are not clear. Literature supports both a pronociceptive/inflammatory role of the A2aR/A2bR and antihyperalgesia/allodynia with A1Rs/A3Rs. Adenosine could participate in the reactivation of chronic regional pain syndrome (CRPS) through inflammatory pathways and via A2Rs.
View Article and Find Full Text PDFDronedarone (a multichannel blocker) enhances the anticonvulsant potency of lamotrigine, but not that of lacosamide, pregabalin and topiramate in the tonic-clonic seizure model in mice.
Epilepsy Res
August 2019
Department of Pathophysiology, Medical University of Lublin, Lublin, Poland. Electronic address:
Accumulating experimental evidence indicates that some recently licensed antiarrhythmic drugs, including dronedarone (a multichannel blocker) play a crucial role in initiation of seizures in both, in vivo and in vitro studies. Some of these antiarrhythmic drugs elevate the threshold for maximal electroconvulsions and enhance the anticonvulsant potency of classical antiepileptic drugs in preclinical studies. This study was aimed at determining the influence of dronedarone (an antiarrhythmic drug) on the anticonvulsant potency of four novel antiepileptic drugs (lacosamide, lamotrigine, pregabalin and topiramate) in the maximal electroshock-induced seizure model in mice.
View Article and Find Full Text PDFOutflow tract ventricular arrhythmias : Electrocardiographic features in relation to mapping and ablation.
Herzschrittmacherther Elektrophysiol
June 2017
Department of Cardiovascular Sciences, Mayo Clinic, 55901, Rochester, MN, USA.
Ventricular arrhythmia arising from the outflow tracts can manifest itself as frequent premature ventricular complexes (PVCs), salvos of ventricular tachycardia (VT), and/or sustained VT. It is amenable to management with medication and catheter ablation without need for an intracardiac defibrillator. The electrocardiogram (ECG) is a crucial tool in the management of these patients as it is can help localize the site of origin, thereby helping guide the electrophysiologist.
View Article and Find Full Text PDFFascicular Ventricular Arrhythmias: Pathophysiologic Mechanisms, Anatomical Constructs, and Advances in Approaches to Management.
Circ Arrhythm Electrophysiol
January 2017
From the Department of Cardiology (S.K., C.V.D., S.J.A.) and Division of Pediatric Cardiology, Department of Pediatrics (S.J.A.), Mayo Clinic College of Medicine, Rochester, MN; and Mayo Clinic Medical School, Rochester, MN (P.G.).
Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia.
Biol Pharm Bull
January 2017
Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University.
Central post-stroke pain (CPSP), a potential sequela of stroke, is classified as neuropathic pain. Although we recently established a CPSP-like model in mice, the effects of adjuvant analgesics as therapeutic drugs for neuropathic pain in this model are unknown. Hence, the aim of the present study was to assess the usefulness of our model by evaluating the effects of adjuvant analgesics used for treating neuropathic pain in this mouse model of CPSP.
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