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A novel ratiometric and colorimetric chemosensor for highly sensitive, selective and ultrafast tracing of HClO in live cells, bacteria and zebrafish.
Anal Chim Acta
May 2021
School of Ophthalmology & Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. Electronic address:
Hypochlorous acid (HClO) along with its ionic form, hypochlorite anion (ClO) are critical reactive oxygen species (ROS), which play vital roles in biological systems. Dysregulated production of HClO/ClO can result in tissue damage and cause a variety of diseases. Besides, Sodium hypochlorite has been widely used as a bleaching agent for water disinfection, surface cleaning in daily life.
View Article and Find Full Text PDF4-Cl-edaravone and ()-2-chloro-3-[()-phenyldiazenyl]-2-butenoic acid are the specific reaction products of edaravone with hypochlorite.
J Clin Biochem Nutr
September 2020
School of Bioscience and Biotechnology, Tokyo University of Technology, 1404-1 Katakura-cho, Hachioji, Tokyo 192-0982, Japan.
3-Methyl-1-phenyl-2-pyrazolin-5-one (edaravone) is a synthetic one-electron antioxidant used as a drug for treatment against acute phase cerebral infarction in Japan. This drug also reacts with two-electron oxidants like peroxynitrite to give predominantly 4-nitrosoedaravone but no one-electron oxidation products. It is believed that this plays a significant role in amelioration of amyotrophic lateral sclerosis.
View Article and Find Full Text PDFA BODIPY Based Fluorescent Probe for the Rapid Detection of Hypochlorite.
J Fluoresc
July 2018
School of Nuclear Science and Technology, Lanzhou University, Lanzhou, Gansu, 730000, People's Republic of China.
A new boron-dipyrromethene (BODIPY) fluorescent dye aimed at sensitively detecting hypochlorite anion (ClO) has been designed, synthesized and characterized. The probe is comprised of a BODIPY fluorophore unit and a ClO specific reactive group of amidoxime. The addition of hypochlorite results in a red-shift of absorption and emission spectra of the probe accompanied by a decrease of intensity and spectra changes (A and 1/I) of the probe can achieve a good linearity to the concentration of ClO.
View Article and Find Full Text PDFThe development of 1,3-diphenylisobenzofuran as a highly selective probe for the detection and quantitative determination of hydrogen peroxide.
Free Radic Res
January 2017
a Faculty of Chemistry , University of Gdansk, Gdansk , Poland.
1,3-Diphenylisobenzofuran (DPBF) has been developed as a selective probe for the detection and quantitative determination of hydrogen peroxide in samples containing different reactive nitrogen and oxygen species (RNOS). DPBF is a fluorescent probe which, for almost 20 years, was believed to react in a highly specific manner toward some reactive oxygen species (ROS) such as singlet oxygen and hydroxy, alkyloxy or alkylperoxy radicals. Under the action of these individuals DPBF has been rapidly transformed to 1,2-dibenzoylbenzene (DBB).
View Article and Find Full Text PDFA high-resolution mitochondria-targeting ratiometric fluorescent probe for detection of the endogenous hypochlorous acid.
Spectrochim Acta A Mol Biomol Spectrosc
September 2016
Molecular Sciences and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha 410082, China.
Hypochlorite anion, one of the biologically important reactive oxygen species, plays an essential role in diverse normal biochemical functions and abnormal pathological processes. Herein, an efficient high-resolution mitochondria-targeting ratiometric fluorescent probe for hypochlorous acid detection has been designed, synthesized and characterized. It is easily synthesized by the condensation reaction (CC) of a 2-(2-hydroxyphenyl) quinazolin-4(3H)-one fluorophore and a cyanine group (mitochondria-targeting), which made the whole molecular a large Stokes shift (210nm) and the two well-resolved emission peaks separated by 140nm.
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