Glutamate-L-cysteine ligase (GLCL [EC 6.3.2.2], also referred to as gamma-glutamylcysteine synthetase) catalyzes the rate-limiting reaction in the synthesis of the important cellular antioxidant glutathione. GLCL is a heterodimer consisting of a catalytic (GLCLC) and a regulatory (GLCLR) subunit. The structure of the human GLCLC subunit gene, GLCLC, which has been mapped to chromosome 6p12, spans 51.4 kb and consists of 16 exons separated by 15 introns.
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| http://dx.doi.org/10.1159/000015505 | DOI Listing |
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