A case of Meigs' syndrome is reported. The patient presented with: hydrothorax, ascites, benign ovarian tumor (thecoma) and increased serum levels of CA 125. Ovarian thecoma is a rare tumor, accounting for less than 1% of all ovarian tumors. When associated with Meigs' syndrome, it can produce a clinical picture similar to that of ovarian carcinoma, but the prognosis is much more favourable. The condition was managed by bilateral salpingo-oophorectomy and hysterectomy. The ascites and hydrothorax disappeared spontaneously after removal of the ovarian tumor and CA 125 level decreased.
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Nature
January 2025
Antarctic Research Centre, Victoria University of Wellington, Wellington, New Zealand.
The fate of the West Antarctic Ice Sheet (WAIS) is the largest cause of uncertainty in long-term sea-level projections. In the last interglacial (LIG) around 125,000 years ago, data suggest that sea level was several metres higher than today, and required a significant contribution from Antarctic ice loss, with WAIS usually implicated. Antarctica and the Southern Ocean were warmer than today, by amounts comparable to those expected by 2100 under moderate to high future warming scenarios.
View Article and Find Full Text PDFCien Saude Colet
January 2025
Serviço de Orientação ao Exercício, Prefeitura Municipal de Vitória. Vitória ES Brasil.
The scope of this article is to analyze the temporal trend and macro-regional distribution of the options on offer in terms of collective activities of bodily practices and physical activities (BPPA) and the number of participants in primary health care, developed by all health professionals and by Physical Education Professionals in Brazil. It involved an ecological time-series study, using data from the Health Information System for Primary Health Care (Sisab) between 2014 and 2022, which was assessed using regression analysis and Joinpoint software. At the national level, the results revealed an increase in the number of collective BPPA activities and participants in primary health care developed by all health professionals and by Physical Education Professionals between 2014 and 2019, followed by a reduction in both in 2020.
View Article and Find Full Text PDFJAMA Dermatol
January 2025
Centre for Molecular Medicine and Biobanking, University of Malta, Malta.
Importance: Variation in nicastrin (NCSTN) is associated with a monogenic subtype of hidradenitis suppurativa. Dysregulation of humoral immunity has been suggested as a potential mechanistic link between NCSTN variation and hidradenitis suppurativa. There is a paucity of biomarkers that can predict disease-associated variation.
View Article and Find Full Text PDFEur J Nucl Med Mol Imaging
January 2025
Institute of Radiation Medicine, Fudan University, Xietu Road 2094, Shanghai, 200032, China.
Objectives: Mesothelin (MSLN) is an antigen that is overexpressed in various cancers, and its interaction with tumor-associated cancer antigen 125 plays a multifaceted role in tumor metastasis. The serum MSLN expression level can be detected using enzyme-linked immunosorbent assay; however, non-invasive visualization of its expression at the tumor site is currently lacking. Therefore, the aim of this study was to develop a molecular probe for imaging MSLN expression through positron emission tomography (PET).
View Article and Find Full Text PDFInt J Surg
January 2025
Department of Liver Transplant Center, Organ Transplant Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, P.R, China.
Objective: T cell-mediated rejection (TCMR) is a major concern following liver transplantation (LT), and identifying its predictors could help improve post-transplant prognosis. This study aimed to develop a model to predict the risk of TCMR in children and adults after LT.
Method: Pre-transplant demographic characteristics, intraoperative parameters, and especially early post-transplant laboratory data for 1,221 LT recipients (1,096 adults and 125 children) were obtained from Hospital, University, between 1 January 2015, and 1 January 2022.
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