Transient erythroblastopenia of childhood (TEC) is an acquired, self-limiting, uncommon disease, characterized by the temporary arrest of red cell production, resulting in moderate to several anemia. We retrospectively evaluated four cases of TEC, identified during an 8-year period of time in our Department of Pediatrics, including one patient, who developed TEC during the course of Kawasaki's syndrome. Clinical and hematological presentations of patients were analyzed and the most recent data of literature were reviewed. In conclusion, we suggest that a better knowledge of this rare and unique hematologic disorder of childhood may help make a correct diagnosis, avoiding unnecessary laboratory tests (e.g. bone marrow aspirate) and inappropriate therapeutic modalities.
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Transient erythroblastopenia of childhood after COVID-19 infection: a case report.
Ital J Pediatr
July 2024
Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Via Luigi De Crecchio, Naples, 80138, Italy.
Article Synopsis
- Transient erythroblastopenia of childhood (TEC) is a rare condition affecting children, typically linked to viral and immune factors, and has now been associated with COVID-19.
- A case is presented of a child with severe red blood cell depletion and absent erythroblasts in the bone marrow after a SARS-CoV-2 infection, showing signs similar to a known severe immune disorder (HLH).
- The report suggests that COVID-19 can induce TEC and emphasizes the need to include it in assessments of patients with unexplained red blood cell production issues, considering its relation to diseases like MIS-C.
Etiologies and Outcomes of Normocytic Anemia in Children.
J Pediatr
August 2024
Division of Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, TX.
Objective: To characterize the evaluation and outcomes of children referred to pediatric hematology for normocytic anemia.
Study Design: Retrospective cohort study of children aged 0-21 years referred to a tertiary pediatric hematology clinic for normocytic anemia from 2019 through 2021. Normocytic anemia was defined as a low hemoglobin and normal mean corpuscular volume, per the referring laboratory reference range.
[A child with persistent anaemia].
Tidsskr Nor Laegeforen
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Case Presentation: A toddler presented with severe anemia with normal red cell indices and a low reticulocyte count.
Transient erythroblastopenia of childhood is a rare, benign, self-limited condition seen in infants and young children. Laboratory studies will show moderate or severe normochromic normocytic anemia accompanied by absent or low reticulocytes, neutropenia, and mild thrombocytosis or thrombocytopenia. The etiology is unclear, but it has been associated with clinical or laboratory evidence of a recent viral syndrome.
View Article and Find Full Text PDFTransient erythroblastopenia due to a GATA1 variant in an infant female.
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Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Diamond-Blackfan anemia (DBA) is a congenital anemia with erythroid cell aplasia. Most of the causative genes are ribosomal proteins. GATA1, a hematopoietic master transcription factor required for erythropoiesis, also causes DBA.
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