Study Objectives: To determine the relationship between D dimer (DD) status and markers of disease activity in patients with sarcoidosis.
Design: Prospective, observational analysis.
Setting: Pulmonary clinic of a tertiary care, university-affiliated hospital.
Patients: Consecutive individuals with newly diagnosed sarcoidosis.
Intervention: Determination of serum DD.
Measurements And Results: The study cohort included 28 subjects, and DD was present in 39.3%. DD status correlated with the radiographic stage of disease (p = 0. 035), diffusing capacity of the lung for carbon monoxide (p = 0.026), serum angiotensin-converting enzyme level (p = 0.006), and the presence of dyspnea (p = 0.034). Patients with circulating DD were 3. 8 times more likely to have radiographic evidence of interstitial involvement. DD was not associated with either FVC or the FEV(1).
Conclusions: DD is frequently positive in patients with sarcoidosis. DD is associated with disease activity as measured by radiograph, pulmonary function tests, and serum markers of inflammation.
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