The minimally invasive approach to olfactory neuroblastoma: combined endoscopic and stereotactic treatment.

Objectives: To describe a new treatment modality of olfactory neuroblastoma consisting of endoscopic nasal and paranasal sinus surgery and stereotactic radiosurgery.

Study Design: Retrospective review of three patients suffering from olfactory neuroblastoma.

Methods: Review of the charts, the computed tomography, and magnetic resonance imaging scans, the operation reports, radiosurgical data, and follow-up.

Results: All three patients remained free of disease with excellent quality of life in respective follow-up periods of 71, 50, and 39 months.

Conclusion: The combination of two minimally invasive therapies, endoscopic sinus surgery and stereotactic radiosurgery, provide a reliable new approach to the treatment of a series of olfactory neuroblastomas that offers excellent quality of life, less injury to the patient, fewer side-effects, and fewer long-term effects than other treatment strategies.