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Polyangiitis Overlap Syndrome: Polyarteritis Nodosa with Leukocytoclastic Vasculitis Associated with Left Ventricular Thrombus and Vocal Cord Palsy: A Case Report.
Oman Med J
July 2024
Department of Medicine, Faculty of Medicine, Royal College of Medicine, Universiti Kuala Lumpur, Perak, Malaysia.
Polyangiitis overlap syndrome (POS) is a systemic vasculitis characterized by overlapping features of more than one well-defined vasculitic syndrome. We present the case of a 38-year-old Malay man with progressive dyspnea and palpable purpura in his lower limbs. The diagnostic evaluation revealed right-sided segmental pulmonary consolidation with pleural effusion, systolic cardiac dysfunction with the presence of an intracardiac thrombus, and left vocal cord palsy secondary to laryngeal mononeuropathy.
View Article and Find Full Text PDFDefining cause of death in a contemporary cohort with ANCA-associated vasculitis (AAV): A comparison of electronic health record and death certificate data.
Semin Arthritis Rheum
December 2024
Department of Medicine, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, 55 Fruit St, Yawkey 4B, Boston, MA, USA.
Objectives: Patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) face excess mortality compared with the general population. Mortality in clinical epidemiology research is often examined using death certificate diagnosis codes; however, the sensitivity of such codes in AAV is unknown.
Methods: We performed a retrospective cohort study using the Mass General Brigham AAV Cohort, including patients with AAV who died between 2002 and 2019.
Association of tyrosine kinase 2 polymorphisms with susceptibility to microscopic polyangiitis in a Guangxi population.
PeerJ
December 2024
Department of Nephrology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Background: Heredity and epigenetics affect the pathogenesis of microscopic polyangiitis (MPA). Tyrosine kinase 2 (TYK2) polymorphisms (rs2304256C > A, rs280519A > G, and rs12720270G > A) may be potential protective factors against anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Current research suggests that TYK2 is associated with various autoimmune diseases; however, no study has examined the relationship between TYK2 polymorphisms and AAV.
View Article and Find Full Text PDFConcurrent Evaluation of Restless Leg Syndrome, Neuropathic Pain, and Quality of Life in Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis: Single-Center Data.
Cureus
November 2024
Division of Rheumatology, Department of Internal Medicine, Erciyes University Faculty of Medicine, Kayseri, TUR.
Objective This study aims to investigate the frequency of restless leg syndrome (RLS) and neuropathic pain (NeP) and their effects on the quality of life (QoL) of patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). Methods The study included 30 patients with AAV and 30 healthy volunteers. Demographic and clinical parameters and laboratory data were recorded.
View Article and Find Full Text PDFANCA-associated vasculitis presenting with progressive binocular manifestations: a case report and literature review.
Front Med (Lausanne)
December 2024
Department of Nephrology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
This report primarily describes a rare case of an elderly male patient who initially presented with central retinal artery occlusion (CRAO) in the left eye and was ultimately diagnosed with anti-neutrophil cytoplasmic antibody (ANCA) -associated vasculitis involving the eyes, gastrointestinal tract, and kidneys. However, due to irregular treatment, both eyes developed progressive ocular manifestations later. This article emphasizes the importance of actively screening for and treating underlying conditions in cases of CRAO.
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