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Comparison of the Incidence and Magnitude of Hyponatremia Among Patients With Poststroke Depression Receiving Either Escitalopram or Sertraline.
Pharmacol Res Perspect
December 2024
Clinical Pharmacy Department, Hamad Medical Corporation, Doha, Qatar.
Article Synopsis
- - Depression is common among stroke survivors, and SSRIs like escitalopram and sertraline are often prescribed, but they can cause low sodium levels (hyponatremia), which may worsen patient outcomes.
- - This study reviewed hospital records from 401 patients over five years to compare the incidence and severity of hyponatremia in those treated with either escitalopram or sertraline.
- - Results showed that both medications were linked to an increased risk of mild hyponatremia, with no significant differences in outcomes between the two drugs, highlighting the need for caution when prescribing these SSRIs.
Hyponatremia Associated with the Use of Common Antidepressants in the All of Us Research Program.
Clin Pharmacol Ther
February 2025
Precision Health Informatics Section, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Article Synopsis
- This study investigates the risk of hyponatremia (low sodium levels) associated with various antidepressants, including SSRIs, SNRIs, and NRIs, through examination of health records in the All of Us Research Program.
- The overall incidence of hyponatremia was found to be 0.87% within the first 30 days and 10.5% over three years among participants taking these medications.
- Among the antidepressants studied, duloxetine and escitalopram had the highest risk for hyponatremia, while bupropion and paroxetine were linked to the lowest risk, helping providers make informed treatment decisions.
Severe Hyponatremia Caused by Sertraline-Induced Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Complication With Critical Implications for Patient Safety.
Cureus
October 2024
Internal Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, USA.
Article Synopsis
- * Hyponatremia, although rare, can lead to critical health problems and was observed in a 68-year-old woman after she started taking sertraline.
- * Healthcare providers should carefully monitor patients on SSRIs for electrolyte levels and adjust treatment plans as needed to prioritize safety in psychiatric care.
Harder, better, faster, stronger? Retrospective chart review of adverse events of interactions between adaptogens and antidepressant drugs.
Front Pharmacol
September 2023
Department of Adult Psychiatry, Chair of Psychiatry, Jagiellonian University Medical College, Kraków, Poland.
We aimed to systematically evaluate the prevalence and clinical characteristics of adverse events associated with the adaptogens and antidepressant drug interactions in a retrospective chart review. A total of 1,816 reports of adverse events were evaluated. Cases were included in the analysis if the pharmacoepidemiological analysis showed the presence of a high probability of a causal relationship between an adaptogen and antidepressant interaction and the occurrence of adverse events.
View Article and Find Full Text PDFSSRI/SNRI -induced Hyponatremia: A Case Series of 26 Patients in a Single Institution from 2018 to 2020.
Psychiatr Q
June 2023
Department of Pharmacy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application (Beijing Hospital), Beijing, 100730, People's Republic of China.
Antidepressant medications are widely used by patients with depression or a depressive disorder. In spite of a generally favorable safety profile of selective serotonin reuptake inhibitors or serotonin - norepinephrine reuptake inhibitors (SSRI/SNRI), several cases of a possible connection between SSRI/SNRI and hyponatremia have been reported. To describe the clinical characteristics of patients with hyponatremia after SSRI/SNRI exposure, and to examine the association between SSRI/SNRI exposure and the presence of hyponatremia in a Chinese population.
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