Resumption of the first meiotic division and extrusion of the first polar body from the cumulus enclosed and cumulus-free oocytes isolated from mouse ovaries in diestrus, proestrus, estrus (I and II) were registered in the medium containing various concentration of verapamil. In this study, the competence of the oocytes to resumed the first meiotic division and to extruded the first polar body were dependent from verapamil concentration (in proestrus and estrus I) and from cumulus cell presence.
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