The CYP19 gene codes for the aromatase enzyme that is involved in the synthesis of oestrogens. This case-control study examines the relationship between a tetranucleotide repeat sequence in the CYP19 gene and the development of male breast cancer. No significant differences were found between male breast cancer cases and controls.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374487 | PMC |
| http://dx.doi.org/10.1054/bjoc.1999.1085 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Adrenomedullin gene delivery rescues estrogen production in Leydig cells via the inhibition of TGF-β1/Smads signaling pathway.
Reprod Toxicol
January 2025
Department of Andrology, The First Affiliated Hospital, Hengyang Medical School, University of South China, China. Electronic address:
Article Synopsis
- The study investigates adrenomedullin's (ADM) role in protecting estrogen production in Leydig cells by targeting the TGF-β1/Smads signaling pathway.
- Treatment with ADM via recombinant adenovirus (Ad-ADM) in Leydig cells improved cell viability and hormone production in the presence of lipopolysaccharide (LPS), a compound that can induce cellular stress.
- Results indicated that Ad-ADM not only maintained testosterone production and aromatase activity but also reduced the harmful effects of TGF-β1 and Smads, suggesting that ADM supports the overall hormone balance in Leydig cells.
Incomplete ovarian function suppression in premenopausal breast cancer patients treated with gonadotropin-releasing hormone agonists.
Cancer Treat Rev
January 2025
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120 Guangzhou, China; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120 Guangzhou, China. Electronic address:
Background: Ovarian function suppression (OFS) has emerged as a crucial adjuvant therapy for premenopausal breast cancer patients. Some patients fail to achieve complete OFS with commonly used OFS drugs. The definition of incomplete OFS remains unclear, and large-scale data on its incidence are lacking.
View Article and Find Full Text PDFAcephate Exposure Induces Transgenerational Ovarian Developmental Toxicity by Altering the Expression of Follicular Growth Markers in Female Rats.
Biology (Basel)
December 2024
Department of Zoology, College of Science, King Saud University, Riyadh P.O. Box 145111, Saudi Arabia.
Acephate is an organophosphate foliar and soil insecticide that is used worldwide. In this study, the transgenerational ovarian developmental toxicity caused by acephate, along with its in utero reprogramming mechanisms, were explored. Thirty female virgin Wistar albino rats were randomly assigned to three groups: one control group and two acephate treatment groups.
View Article and Find Full Text PDFBone Disease Associated with Inactivating Aromatase Mutations and its Management.
Calcif Tissue Int
January 2025
Department of Medicine, Surgery and Neurosciences, University of Siena, Policlinico Santa Maria Alle Scotte, Siena, Italy.
Article Synopsis
- Aromatase deficiency is a rare genetic disorder caused by mutations in the CYP19A1 gene, affecting both males and females, with an incidence of less than 1 in 1,000,000.
- In females, symptoms typically present at birth or in early infancy, focusing on sexual development, while in males, issues usually emerge during or after puberty, leading to delayed diagnosis.
- The paper reviews the skeletal and extraskeletal effects of the condition and discusses strategies for managing bone health in individuals with these mutations.
Endocrine-targeting therapies shift the breast microbiome to reduce estrogen receptor-α breast cancer risk.
Cell Rep Med
December 2024
Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA; Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA; Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address:
Article Synopsis
- Research shows that breast tissue has a unique, changeable microbiome that can be influenced by endocrine-targeting therapies such as tamoxifen.
- Tamoxifen treatment was found to change the diversity of the breast microbiome and increase levels of certain beneficial bacteria, like Lactobacillus, in both mice and primates.
- Probiotic bacteria injections in lab mice not only reduced tumor formation but also affected gene expression related to metabolism, suggesting a link between breast microbiome changes and lower risk of estrogen receptor-positive breast cancer.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!