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Slowing Cognitive Decline in Major Depressive Disorder and Mild Cognitive Impairment: A Randomized Clinical Trial.
JAMA Psychiatry
January 2025
Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Article Synopsis
- Older adults with major depressive disorder (MDD) or mild cognitive impairment (MCI) are at increased risk for cognitive decline, making effective interventions crucial.
- This study aimed to evaluate the effectiveness of combining cognitive remediation (CR) and transcranial direct current stimulation (tDCS) on cognitive decline in older adults with remitted MDD (rMDD) and/or MCI.
- Results indicated that this intervention slowed cognitive decline over time but did not lead to immediate improvements in cognition after 2 months.
Longitudinal Symptom Burden and Pharmacologic Management of Catatonia in Autism with and without Profound Impairment: An Observational Study.
medRxiv
September 2024
Department of Psychiatry, Harvard Medical School, 24 Shattuck Street, Boston, Massachusetts, 02115.
Introduction: Catatonia is a highly morbid psychomotor and affective disorder which can affect autistic individuals with and without profound impairment. Catatonic symptoms are treatable with pharmacotherapy and electroconvulsive therapy, but the longitudinal effectiveness of these treatments has not been described.
Methods: We conducted a prospective observational cohort study of patients with autism and co-morbid catatonia who received outpatient care in a specialized outpatient clinic from July 1, 2021 to May 31, 2024.
Polygenic risk scores for nicotine use and family history of smoking are associated with smoking behaviour.
Drug Alcohol Depend
October 2024
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; German Center for Mental Health (DZPG), partner site Mannheim/Heidelberg/Ulm, Germany. Electronic address:
Introduction: Formal genetics studies show that smoking is influenced by genetic factors; exploring this on the molecular level can offer deeper insight into the etiology of smoking behaviours.
Methods: Summary statistics from the latest wave of the GWAS and Sequencing Consortium of Alcohol and Nicotine (GSCAN) were used to calculate polygenic risk scores (PRS) in a sample of ~2200 individuals who smoke/individuals who never smoked. The associations of smoking status with PRS for Smoking Initiation (i.
Evaluation of postoperative delirium in geriatric patients given acetaminophen with and without melatonin: A retrospective cohort study.
Int J Psychiatry Med
August 2024
PGY-2 Internal Medicine Pharmacy Residency, Medical University of South Carolina (MUSC), Charleston, SC, USA.
Article Synopsis
- Postoperative delirium is a serious condition that can lead to various negative outcomes, and using non-opioid pain management, such as melatonin with acetaminophen, may help prevent it.
- A study of patients aged 65 and older showed that those receiving a combination of acetaminophen and melatonin after orthopedic surgery had a significantly lower rate of delirium (5%) compared to those who received only acetaminophen (25%).
- While the combination treatment did not affect 30-day hospital readmissions, it was associated with a slightly longer hospital stay (5 days versus 4 days for acetaminophen alone).
Investigating in VigiBase over 6000 cases of pneumonia in clozapine-treated patients in the context of the literature: focus on high lethality and the association with aspiration pneumonia.
Expert Opin Drug Metab Toxicol
August 2024
Department of Internal Medicine, Dermatology and Psychiatry and Instituto Universitario de Neurociencia (IUNE), Universidad de La Laguna, La Laguna, Canary Islands, Spain.
Article Synopsis
- The study analyzes data from the VigiBase™ database to assess the occurrence of pneumonia and aspiration pneumonia in clozapine-treated patients up to May 2023.
- A total of 6,392 pneumonia cases were reported, with a significant association between aspiration pneumonia and certain co-medications like olanzapine and risperidone.
- Key findings suggest that at least 30% of pneumonia cases in clozapine-treated patients may be aspiration pneumonia, and that adjusting medication regimens and titration practices could reduce associated risks.
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