The purpose of this article is to describe the professional literature and current controversies concerning the relationship between essential fatty acids, especially Docohexaenoic Acid (DHA), and neurologic function. Although there is debate in the literature concerning just how much DHA is required for optimal neurologic functioning of infants, it is known that adequate DHA levels are dependent on an adequate dietary intake. However, common dietary practices today may not provide enough DHA. Because pregnancy and lactation are key times of rapid brain growth for the developing fetus and infant, nurses can be instrumental in teaching pregnant and lactating women diet-related information and promoting practices that help increase DHA levels. By understanding the importance of DHA in pregnancy and infancy, the nurse can take a more active role in essential health education.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1097/00005721-200003000-00005 | DOI Listing |
Alzheimers Dement
December 2024
University of the Balearic Islands, Palma de Mallorca, Spain.
Background: Reactive astrocytes and neuron death by excitotoxicity are observed in Alzheimer's disease (AD). DHA-H (2-hydroxy-docosahexaenoic acid; 2-OH-C22:6 n-3) is a molecule under development that has demonstrated therapeutic efficacy in both cellular and 5xFAD mouse model of AD. DHA-H is metabolized through α-oxidation to yield HPA (Heneicosapentaenoic acid; C21:5 n-3).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Georgia, College of Pharmacy, Athens, GA, USA.
Background: Lipids are key modulators in the pathogenesis of Alzheimer's disease (AD). Dysregulation of lipid homeostasis may disrupt the blood brain barrier, alter myelination, disturb cellular signaling and cause abnormal processing of the amyloid precursor protein. The purpose of this scoping review was to evaluate fatty acid supplementation in patients with AD.
View Article and Find Full Text PDFTop Companion Anim Med
January 2025
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616 USA.
Fish oil supplements for dogs are used therapeutically for various clinical conditions. However, products may be variable in quality, potency, and stability. The objective of this study was to analyze eleven canine fish oil supplements from two time points (2010 and 2021) for the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), polychlorinated biphenyl (PCB) arochlors, minerals, and vitamins A and D, and to compare their compositions to label claims.
View Article and Find Full Text PDFTalanta
January 2025
College of Chemistry and Materials, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang, 330022, China.
Levels of CA125 are strongly associated with cervical, pancreatic, bowel and breast cancer. However, the common CA125 detection method has the disadvantages of poor repeatability, high cost, easy to be disturbed and poor stability. In this work, a COF based electrochemical immunosensor was developed for the rapid, sensitive and stable detection of CA125.
View Article and Find Full Text PDFPharmaceutics
December 2024
Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, College of Pharmacy, Shihezi University, Shihezi 832003, China.
With the increase of reactive oxygen species (ROS) production, cancer cells can avoid cell death and damage by up-regulating antioxidant programs. Therefore, it will be more effective to induce cell death by using targeted strategies to further improve ROS levels and drugs that inhibit antioxidant programs. Considering that dihydroartemisinin (DHA) can cause oxidative damage to protein, DNA, or lipids by producing excessive ROS, while, disulfiram (DSF) can inhibit glutathione (GSH) levels and achieve the therapeutic effect by inhibiting antioxidant system and amplifying oxidative stress, they were co-loaded onto the copper peroxide nanoparticles (CuO) coated with copper tannic acid (Cu-TA), to build a drug delivery system of CuO@Cu-TA@DSF/DHA nanoparticles (CCTDD NPs).
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!