HIV vaccine development has been hampered by the inability of conventional immunogens to elicit antibodies capable of neutralizing primary isolates of the virus. Recent studies using 'fusion-competent' immunogens that capture transitional intermediate structures of the functioning envelope protein suggest that this goal may now be achievable.
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Distinct morphological drivers of jumping and maneuvering performance in gerbils.
J Exp Biol
January 2025
Department of Ecology, Evolution, and Organismal Biology, Brown University, Providence, RI, USA.
Theoretically, animals with longer hindlimbs are better jumpers, while those with shorter hindlimbs are better maneuverers. Yet experimental evidence of this relationship in mammals is lacking. We compared jump force and maneuverability in a lab population of Mongolian gerbils (Meriones unguiculatus).
View Article and Find Full Text PDFModifying reaction time tasks parameters in the automated IntelliCage identifies heightened impulsivity and impaired attention in the 3xTg-AD model of Alzheimer's disease.
Front Aging Neurosci
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Arizona State University-Banner Neurodegenerative Disease Research Center at the Biodesign Institute, Arizona State University, Tempe, AZ, United States.
Background: The 3xTg-AD transgenic mouse model of Alzheimer's disease (AD) is an important tool to investigate the relationship between development of pathological amyloid-β (Aβ) and tau, neuroinflammation, and cognitive impairments. Traditional behavioral tasks assessing aspects of learning and memory, such as mazes requiring spatial navigation, unfortunately suffer from several shortcomings, including the stress of human handling and not probing species-typical behavior. The automated IntelliCage system was developed to circumvent such issues by testing mice in a social environment while measuring multiple aspects of cognition.
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Sci Rep
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Rochester Institute of Technology, Center for Imaging Science, Rochester, NY, 14620, USA.
There is a critical need to understand how aging visual systems contribute to age-related increases in vehicle accidents. We investigated the potential contribution of age-related detriments in steering based on optic flow, a source of information known to play a role in navigation control. Seventeen younger adults (mean age: 21.
View Article and Find Full Text PDFResearch on Gas Explosion Pressure and Flame Propagation Characteristics in Turning Pipelines.
ACS Omega
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College of Safety Science and Engineering, Henan Polytechnic University, Jiaozuo, Henan 454000, China.
In order to investigate the overpressure and flame propagation characteristics of gas explosions in turning pipelines, this study designed a transparent organic glass pipeline test system with different turning angles (30°, 60°, 90°, 120°, and 150°) and conducted a series of experimental studies to analyze the explosion shock wave overpressure and flame propagation behavior. The experimental results show that with the increase of the turning angle of the pipeline, the overpressure of the explosion shock wave significantly increases. In terms of flame propagation characteristics, when the turning angle is small, the flame can adhere to the outer wall of the pipeline corner and gradually fill the entire pipeline section.
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Clinic for Electrophysiology, Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum, Med. Fakultät OWL (Universität Bielefeld), Bad Oeynhausen, 32545, Germany.
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