An AFM probe with integrated piezoresistive read-out has been developed and applied as a cantilever-based environmental sensor. The probe has a built-in reference cantilever, which makes it possible to subtract background drift directly in the measurement. Moreover, the integrated read-out facilitates measurements in liquid. The probe has been successfully implemented in gaseous as well as in liquid experiments. For example, the probe has been used as an accurate and minute thermal sensor and as a humidity sensor. In liquid, the probe has been used to detect the presence of alcohol in water.
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http://dx.doi.org/10.1016/s0304-3991(99)00148-5 | DOI Listing |
Langmuir
March 2025
NanoBiosensors and Biodevices Lab, School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
Elevated nitrate (NO) levels in potable water due to anthropogenic and geogenic activities pose a significant environmental threat. Herein, we report a highly efficient electrochemical sensor device for NO detection using a copper-anchored magnetite (Cu@FeO) nanocomposite. The electrochemical performance of the NO sensor was highly durable and reliable on a glassy carbon electrode (GCE) and as a proof of concept, it has been translated to thermal vapor deposited gold electrodes (Au electrodes) chip integrated with a hand-held portable potentiostat connected to a smartphone with read out capabilities for onsite real field application.
View Article and Find Full Text PDFHost connectivity for invasive, high-density neural probes that integrate all the circuits needed for insitu digitization of brain activity in the shank requires a thin and conformal cable. To minimize tissue damage during insertion or from micro-movements during chronic use, the wiring must be constrained in size with a low number of interconnects. Reducing the number of traces results in thinner and more flexible cables and allows the data rate to be increased by using wider traces.
View Article and Find Full Text PDFIEEE Trans Neural Syst Rehabil Eng
January 2025
Binocular disparate stimulation based on steady-state visual evoked potentials (SSVEP) generates more recognizable features but also introduces complexity hardening the interpretability of SSVEP responses. The individual contribution of each visual pathway when stimulating parts of the visual field remains unclear and is further obfuscated by the large spatial integration of EEG systems. We propose "independent visual field stimulation" (IVFS), utilizing a head-mounted display (HMD) as a novel experimental paradigm to improve the interpretability of SSVEP responses.
View Article and Find Full Text PDFNat Commun
February 2025
Institut für Medizinische Mikrobiologie, Universität Zürich, Zurich, Switzerland.
The accuracy of protein synthesis and its relation to ageing has been of long-standing interest. To study whether spontaneous changes in the rate of ribosomal error occur as a function of age, we first determined that stop-codon readthrough is a more sensitive read-out of mistranslation due to codon-anticodon mispairing than missense amino acid incorporation. Subsequently, we developed knock-in mice for in-vivo detection of stop-codon readthrough using a gain-of-function Kat2-TGA-Fluc readthrough reporter which combines fluorescent and sensitive bioluminescent imaging techniques.
View Article and Find Full Text PDFAntibodies (Basel)
February 2025
Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden.
(1) Background: Single-cell multi-omics is a powerful method for the dissection and detection of complicated immunologic functions and synapses. However, most currently available technologies merge datasets of different omics from separate portions of the same sample to generate combined multi-omics. This process is a source of bias, mainly in the field of immunology on cells originating from pluripotent hematopoietic stem cells with high flexibility during maturation.
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