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The activity of a novel series of peptidomimetic hematoregulatory compounds, designed based on a pharmacophore model inferred from the structure activity relationships of a peptide SK&F 107647 (1), is reported. These compounds induce a hematopoietic synergistic factor (HSF) which in turn modulates host defense. The compounds may represent novel therapeutic agents in the area of hematoregulation.
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| http://dx.doi.org/10.1016/s0960-894x(00)00036-6 | DOI Listing |
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Novel peptidomimetic hematoregulatory compounds.
Bioorg Med Chem Lett
March 2000
Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, Collegeville, PA 19426, USA.
The activity of a novel series of peptidomimetic hematoregulatory compounds, designed based on a pharmacophore model inferred from the structure activity relationships of a peptide SK&F 107647 (1), is reported. These compounds induce a hematopoietic synergistic factor (HSF) which in turn modulates host defense. The compounds may represent novel therapeutic agents in the area of hematoregulation.
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