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Translating evidence into practice: Managing electrolyte imbalances and iron deficiency in heart failure.
Eur J Intern Med
January 2025
Department of Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Lower Saxony, Germany. Electronic address:
Article Synopsis
- Mineral abnormalities, including dyskalaemia, hyponatraemia, hypomagnesaemia, and iron deficiency, are common in heart failure (HF) and are linked to worse health outcomes and increased mortality rates.
- The imbalance in these minerals is influenced by factors like neurohumoral activation, effects of HF medications, and chronic conditions like kidney disease.
- Iron deficiency, affecting up to 60% of HF patients, is particularly serious, but iron replacement therapy has shown benefits, especially in patients with reduced and preserved ejection fractions.
Uroabdomen secondary to spontaneous bladder rupture in a dog with dystocia.
J Vet Emerg Crit Care (San Antonio)
October 2024
Department of Small Animal Clinical Sciences, Texas A&M University Veterinary Teaching Hospital, College Station, Texas, USA.
Objective: To describe the development of uroabdomen secondary to spontaneous bladder rupture in a dog with dystocia.
Case Summary: A 2-year-old intact female Boston Terrier was referred for prolonged labor of 72 hours. At presentation, the dog had delivered 8 puppies at home, with the last pup being stillborn.
A Rare Presentation of Endocarditis with Acute Heart Failure.
J Community Hosp Intern Med Perspect
January 2024
Department of Internal Medicine, Hackensack Meridian Health, Palisades Medical Center, NJ, USA.
is an occupation-related infection that can be found in farm animals or marine life. This infection can present with a spectrum of infection ranging from local cellulitis to aortic endocarditis. Developing endocarditis is rare from this organism with only a few case reports in the literature.
View Article and Find Full Text PDFEvaluation and Management of Hyponatremia in Heart Failure.
Curr Heart Fail Rep
June 2024
Centre for Cardiovascular Diseases, University Hospital Brussels, Laarbeeklaan 101, 1090, Jette, Belgium.
Purpose Of Review: To provide a contemporary overview of the pathophysiology, evaluation, and treatment of hyponatremia in heart failure (HF).
Recent Findings: Potassium and magnesium losses due to poor nutritional intake and treatment with diuretics cause an intracellular sodium shift in HF that may contribute to hyponatremia. Impaired renal blood flow leading to a lower glomerular filtration rate and increased proximal tubular reabsorption lead to an impaired tubular flux through diluting distal segments of the nephron, compromising electrolyte-free water excretion.
Preliminary Report of Intravenous Tolvaptan Sodium Phosphate (Samtas) Treatment in Decompensated Heart Failure.
J Clin Med
January 2024
Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Tolvaptan sodium phosphate (Samtas; Otsuka Pharmaceutical, Tokyo, Japan) is a novel intravenous aquaretic diuretic aimed at individuals experiencing advanced congestion refractory to conventional diuretics and having difficulty with oral intake. Despite its potential, the true efficacy and practicality of this compound within real-world clinical settings remain obscure. A retrospective analysis of clinical data was conducted, examining trends among consecutive in-hospital patients diagnosed with congestive heart failure who underwent treatment with tolvaptan sodium phosphate at a prominent academic medical center between June 2022 and June 2023.
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