We present the results of the numerical simulation of the flow in the nasal cavity, going from the tip of the nostril to the nasopharyngeal region. The volume of the nasal cavity, obtained from axial and coronal scans, takes into account the geometries of the nasal valve and turbinates. The simulation is carried out with the FLUENT code which solves the equations of fluid mechanics. The obtained results for the inspiratory phase are analyzed from the velocities and pressures, paying special attention to the separation of the streamlines in the region located between the middle meatus and the olfactory area. The presented results show the potential of simulation when used in parallel with the clinical approach.
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Ultrasound Med Biol
January 2025
Institute of Biomedical Technologies, Auckland University of Technology, Auckland City, 1010, Auckland, New Zealand. Electronic address:
Objective: This study aims to evaluate the viability of a hypothesis for selective targeting of skin cancer cells by exploiting the spectral gap with healthy cells using analytical and numerical simulation.
Methods: The spectral gap was first identified using a viscoelastic dynamic model, with the physical and mechanical properties of healthy and cancerous skin cells deduced from previous experimental studies conducted on cell lines. The outcome of the analytical simulation was verified numerically using modal and harmonic analysis.
Ecotoxicol Environ Saf
January 2025
Chair of Engineering Hydrology and Water Management, Technical University of Darmstadt, Darmstadt, Germany. Electronic address:
River quality management involves complex challenges due to inherent uncertainties in various parameters, especially when dealing with controllable and uncontrollable pollutants. This study integrates a finite volume approach, called SEF (symmetric exponential function), with Monte Carlo simulations in MATLAB to solve the advection-dispersion equation, focusing on evaluating river quality protection tools by considering failure probability (P). Critical specifications for maintaining reliable river ecosystem performance are identified.
View Article and Find Full Text PDFBiometrics
January 2025
Department of Statistics and Data Science, National University of Singapore, Singapore 117546, Singapore.
Pharmacogenomics stands as a pivotal driver toward personalized medicine, aiming to optimize drug efficacy while minimizing adverse effects by uncovering the impact of genetic variations on inter-individual outcome variability. Despite its promise, the intricate landscape of drug metabolism introduces complexity, where the correlation between drug response and genes can be shaped by numerous nongenetic factors, often exhibiting heterogeneity across diverse subpopulations. This challenge is particularly pronounced in datasets such as the International Warfarin Pharmacogenetic Consortium (IWPC), which encompasses diverse patient information from multiple nations.
View Article and Find Full Text PDFChaos
January 2025
Department of Mathematics, Xi'an University of Science and Technology, Xi'an 710054, People's Republic of China.
The existing research studies on the basin stability of stochastic systems typically focus on smooth systems, or the attraction basins are pre-defined as easily solvable regular basins. In this work, we introduce a new framework to discover the basin stability from state time series in the non-smooth stochastic competition system under threshold control. Specifically, we approximate the drift and diffusion with threshold control parameters by an extended Kramers-Moyal expansion with initial state partitioning.
View Article and Find Full Text PDFNucleic Acids Res
January 2025
Quantitative Biology Group, University of Belgrade - Faculty of Biology, Studentski trg 16, Belgrade11000, Serbia.
Type II restriction-modification (R-M) systems play a pivotal role in bacterial defense against invading DNA, influencing the spread of pathogenic traits. These systems often involve coordinated expression of a regulatory protein (C) with restriction (R) enzymes, employing complex feedback loops for regulation. Recent studies highlight the crucial balance between R and M enzymes in controlling horizontal gene transfer (HGT).
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