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ADAM10 Expression by Ameloblasts Is Essential for Proper Enamel Formation.
Int J Mol Sci
December 2024
Division of Biosciences, College of Dentistry, Ohio State University, 305 W, 12th Ave., Columbus, OH 43210, USA.
ADAM10 is a multi-functional proteinase that can cleave approximately 100 different substrates. Previously, it was demonstrated that ADAM10 is expressed by ameloblasts, which are required for enamel formation. The goal of this study was to determine if ADAM10 is necessary for enamel development.
View Article and Find Full Text PDFHSF5 Deficiency Causes Male Infertility Involving Spermatogenic Arrest at Meiotic Prophase I in Humans and Mice.
Adv Sci (Weinh)
September 2024
Department of Obstetrics/Gynecology, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Meiosis is a specialized cell division process that generates gametes for sexual reproduction. However, the factors and underlying mechanisms involving meiotic progression remain largely unknown, especially in humans. Here, it is first showed that HSF5 is associated with human spermatogenesis.
View Article and Find Full Text PDFAtorvastatin Promotes Pro/anti-inflammatory Phenotypic Transformation of Microglia via Wnt/β-catenin Pathway in Hypoxic-Ischemic Neonatal Rats.
Mol Neurobiol
June 2024
Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), NHC Key Laboratory of Chronobiology, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Inflammatory reaction plays a key role in the pathogenesis of hypoxic-ischemic encephalopathy (HIE) in neonates. Microglia are resident innate immune cells in the central nervous system and are profoundly involved in neuroinflammation. Studies have revealed that atorvastatin exerts a neuroprotective effect by regulating neuroinflammation in adult animal models of brain stroke and traumatic brain injury, but its role regarding damage to the developing brain remains unclear.
View Article and Find Full Text PDFCircadian misalignment promotes vascular smooth muscle cell apoptosis via defective autophagy.
J Mol Histol
August 2021
Department of Vascular Surgery, Qingpu Branch of Zhongshan Hospital, Fudan University, 1158 Park Road, Qingpu, Shanghai, 201700, China.
Defective autophagy in vascular smooth muscle cells (VSMCs) in response to oxidative stress can lead to cellular apoptosis and plaque instability. Previous studies have revealed that the circadian clock system is involved in autophagic regulation and plaque progression. However, the mechanism by which circadian rhythmicity influences VSMC autophagy and plaque stability remains unclear.
View Article and Find Full Text PDFAdverse effects of circadian desynchrony on the male reproductive system: an epidemiological and experimental study.
Hum Reprod
July 2020
Key Lab of Medical Protection for Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Study Question: Is circadian desynchrony a risk factor of male reproductive damage in semen parameters and/or reproductive hormones?
Summary Answer: Circadian desynchrony correlates with decrease of sperm count, which was improved when circadian desynchrony was attenuated.
What Is Known Already: Circadian desynchrony caused by work (shift work) and non-work-related reasons is prevalent worldwide and has been found to be associated with decreased female fertility, but whether it harms male reproductive health is unclear.
Study Design, Size, Duration: A hybrid research was conducted.
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