AI Article Synopsis
- The study examined the distribution of silver-stained particles (SSPs) in AgNORs of human and rat proerythroblasts, focusing on immature and rapidly dividing cells.
- Most proerythroblasts showed an asymmetric distribution of SSPs, with a dominant nucleolus containing more of these components, suggesting it has a key role in biosynthetic activity.
- As proerythroblasts mature, this asymmetric pattern diminishes, leading to the presence of fewer, single SSPs in the terminal stages of erythroblast development.
Article Abstract
The distribution of SSPs representing AgNORs was studied in human as well as rat proerythroblasts to provide information on the distribution of these nucleolar components in highly immature and proliferating non-neoplastic cells. The distribution of SSPs was asymmetric and most of the cells contained one nucleolus which possessed a larger number of these nucleolar components than the remaining nucleoli. Such nucleolus might be functionally dominant, since the number of nucleolar SSPs is apparently related to the nucleolar biosynthetic activity. On the other hand, when a proerythroblast possessed only one nucleolus, the number of SSPs in such a cell was very similar to the sum of SSPs in a polynucleolar cell. The asymmetric distribution of SSPs characteristic for most proerythroblasts disappeared in the terminal stages of the erythroblastic development. Cells in such stages, as described previously, were characterized by the presence of a limited number of single SSPs.
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