AI Article Synopsis
- An antiserum against purified lipopolysaccharide (LPS) from Vibrio cholerae O1 strain Co366 provided passive protection from infection by O1 strains but not by O139 or non-O1/non-O139 strains.
- The IgG fraction of the antiserum was effective in preventing intestinal adherence and colonization by O1 strains, while the monovalent Fab(IgG) fragment offered only minimal protection.
- The study suggests that LPS may not be directly involved in the colonization of the intestine by vibrios, as purified LPS did not inhibit colonization, indicating that anti-LPS antibodies might protect by preventing adherence through microagglutination or immobilization of the bacteria.
Article Abstract
An antiserum raised against purified lipopolysaccharide (LPS) of a Vibrio cholerae O1 strain (Co366) induced passive protection against challenge with the parent as well as other O1 organisms but not against O139 or non-O1/non-O139 organisms. A considerable level of protection against O1 strains was also observed with the IgG fraction of the antiserum which inhibited intestinal adherence and colonisation. The monovalent Fab(IgG) fragment, on the other hand, showed only a low level of protection. Interestingly, purified LPS failed to inhibit intestinal colonisation by the parent strain (Co366), thereby suggesting that the cell surface LPS moieties of vibrios may not be directly involved in the colonisation process. It may be concluded that the anti-LPS antibodies induce passive protection through microagglutination and/or immobilisation of vibrios which do not allow the organisms to adhere to and colonise the intestine.
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| http://dx.doi.org/10.1111/j.1574-6968.2000.tb09036.x | DOI Listing |
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