This is the first microdialysis report comparing concentrations (pg/microliter) of norepinephrine (NE), serotonin (5-HT) and dopamine (DA) derived from feline locus ceruleus complex (LC) and amygdala. NE and 5-HT declined progressively from waking to slow-wave-sleep (SWS) and then to rapid-eye-movement (REM) sleep. Concentrations of DA did not change at either collection site across the sleep-wake cycle. We conclude that release of NE and 5-HT release modulates physiologic components related to the sleep-wake cycle, but DA does not.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0006-8993(00)02013-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Protective effect of essential oil inhalation on neuromodulators regulating the sleep/wake cycle in rats with total sleep deprivation.
Iran J Basic Med Sci
January 2025
Department of Physiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
Objectives: This study aimed to investigate the potential effects of different doses of essential oil (Lavender EO) administered by inhalation on sleep latency and neuromodulators regulating the sleep/wake cycle in rats with total sleep deprivation (TSD).
Materials And Methods: Forty-eight male Sprague-Dawley rats were divided into five groups: Control, Alprazolam (ALP, 0.25 mg/kg given intraperitoneally), L1 (Lavender EO, 0.
Impact of Varying Sleep Pressure on Daytime Sleep Propensity in Healthy Young and Older Adults.
Clocks Sleep
January 2025
Circadian Physics Group, School of Physics, University of Sydney, Sydney, NSW 2006, Australia.
Fixed sleep schedules with an 8 h time in bed (TIB) are used to ensure participants are well-rested before laboratory studies. However, such schedules may lead to cumulative excess wakefulness in young individuals. Effects on older individuals are unknown.
View Article and Find Full Text PDFBimodal Patterns of Locomotor Activity and Sleep in : A Model for Their Simulation.
Nat Sci Sleep
January 2025
Department of Insect Genetics, Institute of Cytology and Genetics of the Siberian Branch, the Russian Academy of Sciences, Novosibirsk, 630090, Russia.
Purpose: Two previously proposed modelling approaches to explain the bimodal pattern of activity and/or sleep in are based on 1) the concept of morning and evening oscillators underlying the peaks of activity in the morning and evening, respectively, and 2) the concept of two cycles of buildup and decay of sleep pressure, gated only by the circadian oscillator. Previously, we simulated 24-h alertness-sleepiness curves in humans using a model postulating the circadian modulation of the buildup and decay phases of two (wake and sleep) homeostatic processes. Here, we tested whether a similar model could be applied to simulate the bimodal 24-h rhythm of fly locomotor activity and sleep.
View Article and Find Full Text PDFInclusion of hypocretin-1 improved performance of poor sleep quality prediction for elderly patients with acute ischemic stroke: a prospective cohort study.
Front Aging Neurosci
January 2025
School of Nursing, Capital Medical University, Beijing, China.
Background: Hypocretin-1 is a vital neurotransmitter in regulating the sleep-wake cycle and provides neuroprotection against cerebral ischemia. We aims to develop a poor sleep quality predictive model for elderly population with acute ischemic stroke.
Methods: A total of 183 consecutively elderly patients were included in the prospective cohort study.
Genetic and epigenetic alterations in night shift nurses with breast cancer: a narrative review.
Cancer Cell Int
January 2025
School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
This narrative review explores the link between breast cancer and night shift work in nurses, focusing on genetic and epigenetic factors. Breast cancer disproportionately affects women globally, and night shift work is increasingly recognized as a potential risk factor. Nurses who work consecutive overnight shifts face elevated risks due to disruptions in their circadian rhythms.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!