Simulation of magnetic resonance spectra of probes in partially ordered glasses requires in principle a numerical integration on the full set of three Euler angles omega=(alpha beta gamma) from a laboratory fixed to a molecule fixed reference frame. It is shown that it is possible to manage efficiently this problem by using the algebraic properties of the Wigner matrix elements. This analysis is applied to time resolved EPR (TREPR) spectra of a series of bis-adducts of C60 in the ordered glass of a nematic liquid crystal solvent. A paramagnetic triplet state is created by light excitation and TREPR spectra are obtained with the external magnetic field set parallel or perpendicular to the director n of the mesophase. The preferred orientation in the mesophase of the triplet state zero field tensor is determined.
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http://dx.doi.org/10.1016/s1386-1425(99)00237-1 | DOI Listing |
J Leukoc Biol
January 2025
Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA.
Regulated sequential exocytosis of neutrophil granules is essential in orchestrating the innate immune response, while uncontrolled secretion causes inflammation. We developed and characterized Nexinhib20, a small-molecule inhibitor that targets azurophilic granule exocytosis in neutrophils by blocking the interaction between the small GTPase Rab27a and its effector JFC1. Its therapeutic potential has been demonstrated in several pre-clinical models of inflammatory disease.
View Article and Find Full Text PDFNucleic Acids Res
January 2025
Department of Medicine, UofL Health Brown Cancer Center, University of Louisville, Louisville KY, 505 S Hancock St, Louisville, KY 40202, United States.
Time-resolved small-angle X-ray experiments are reported here that capture and quantify a previously unknown rapid collapse of the unfolded oligonucleotide as an early step in the folding of hybrid 1 and hybrid 2 telomeric G-quadruplex structures. The rapid collapse, initiated by a pH jump, is characterized by an exponential decrease in the radius of gyration from 24.3 to 12.
View Article and Find Full Text PDFEur Heart J Cardiovasc Imaging
January 2025
PULS/e group, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Aims: Image-based, patient-specific rupture risk analysis of AAAs is promising but it is limited by invasive and costly imaging modalities. Ultrasound (US) offers a safe, more affordable alternative, allowing multiple assessments during follow-up and enabling longitudinal studies on AAA rupture risk.
Methods And Results: This study used time-resolved three-dimensional US to assess AAA rupture risk parameters over time, based on vessel and intraluminal thrombus (ILT) geometry.
Front Public Health
January 2025
Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
Background: Inflammation is a critical component in the process of resolved hepatitis B virus (HBV) infection. The neutrophil-to-lymphocyte ratio (NLR) serves as a sensitive indicator of systemic inflammation and immune activation. Our study aimed to investigate the correlation between elevated NLR levels and the risk of all-cause mortality in patients with resolved HBV infection.
View Article and Find Full Text PDFDigit Discov
January 2025
Department of Chemical and Biomolecular Engineering, North Carolina State University Raleigh North Carolina 27606 USA
Plastic pollution, particularly microplastics (MPs), poses a significant global threat to ecosystems and human health, necessitating innovative remediation strategies. Biocompatible and biodegradable plastic-binding peptides (PBPs) offer a potential solution through targeted adsorption and subsequent MP detection or removal from the environment. A challenge in discovering plastic-binding peptides is the vast combinatorial space of possible peptides (, over 10 for 12-mer peptides), which far exceeds the sample sizes typically reachable by experiments or biophysics-based computational methods.
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