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2'- -ribose methylation of the first transcribed base (adenine or A in SARS-CoV-2) of viral RNA mimics the host RNAs and subverts the innate immune response. How nsp16, with its obligate partner nsp10, assembles on the 5'-end of SARS-CoV-2 mRNA to methylate the A has not been fully understood. We present a ∼ 2.
View Article and Find Full Text PDFPlasma-activated media selectively induces apoptotic death via an orchestrated oxidative stress pathway in high-grade serous ovarian cancer cells.
Mol Oncol
December 2024
Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, Australia.
Article Synopsis
- * The standard treatment—surgery and chemotherapy—causes significant side effects and reduces patients' quality of life, highlighting the need for new, less toxic therapies.
- * Research on plasma-activated media (PAM) shows it may be more effective than traditional chemotherapy, promoting cancer cell death and oxidative stress in HGSOC, paving the way for future clinical applications.
On the Cranial Nerves.
NeuroSci
March 2024
Instituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91190, Mexico; (J.M.); (F.R.-D.); (G.E.A.-A.); (L.I.G.-H.); (G.A.C.-Á.); (D.H.-C.); (C.A.P.-E.); (M.R.T.-C.).
The twelve cranial nerves play a crucial role in the nervous system, orchestrating a myriad of functions vital for our everyday life. These nerves are each specialized for particular tasks. Cranial nerve I, known as the olfactory nerve, is responsible for our sense of smell, allowing us to perceive and distinguish various scents.
View Article and Find Full Text PDFRNA splicing controls organ-wide maturation of postnatal heart in mice.
Dev Cell
January 2025
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China; Shenzhen Key Laboratory of Cardiovascular Disease, Fuwai Hospital Chinese Academy of Medical Sciences-Shenzhen, Shenzhen 518057, China; Key Laboratory of Application of Pluripotent Stem Cells in Heart Regeneration, Chinese Academy of Medical Sciences, Beijing 100037, China. Electronic address:
Postnatal cardiac development requires the orchestrated maturation of diverse cellular components for which unifying control mechanisms are still lacking. Using full-length sequencing, we examined the transcriptomic landscape of the maturating mouse heart (E18.5-P28) at single-cell and transcript isoform resolution.
View Article and Find Full Text PDFDisordered regions of human eIF4B orchestrate a dynamic self-association landscape.
Nat Commun
October 2024
University of Bordeaux, Inserm, CNRS, ARNA Laboratory, U1212, UMR 5320, Institut Européen de Chimie et Biologie, F-33600, Pessac, France.
Article Synopsis
- Eukaryotic translation initiation factor eIF4B is crucial for effective cap-dependent translation, is commonly overexpressed in cancer cells, and may play a role in stress granule formation.
- Due to its high intrinsic disorder, eIF4B is often not seen in cryo-EM studies of translation complexes, with most observations limited to its structured RNA recognition motif domain.
- Research incorporating experiments and simulations reveals that eIF4B's intrinsically disordered region (IDR) helps transition from monomers to larger dynamic oligomers, influenced by factors like ionic strength and molecular crowding, hinting at potential regulatory mechanisms affecting its behavior in cells.
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