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Case report: Anesthesia management for surgical treatment of glucagonoma with symptom of characterized necrolytic migratory erythema.
Front Oncol
December 2024
Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, China.
Background: The anesthetic management of patients with glucagonoma is complicated by a number of factors including glucose fluctuation, characterized necrolytic migratory erythema in oral and pharyngeal, which may lead to an unexpected difficult airway.
Case Presentation: Herein we describe the anesthetic considerations and management of a 47-year-old adult with glucagonoma, who presented for a laparoscopic splenectomy and distal pancreatectomy procedure.
Conclusion: This report details fiberoptic intubation in an adult with glucagonoma and necrolytic migratory erythema.
Necrolytic migratory erythema: a fortuitous diagnosis.
BMJ Case Rep
November 2024
Dermatology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
A woman in her late 60s presented with widespread, itchy, dark lesions over her trunk and legs for 1 month. Initially, she was managed as nutritional dermatitis and experienced partial improvement. However, her condition worsened over 2 months, characterised by aggravated skin lesions, new-onset diabetes and a 12 kg weight loss.
View Article and Find Full Text PDFGlucagon-Producing Pancreatic Neuroendocrine Tumors (Glucagonomas) are Enriched in Aggressive Neoplasms with ARX and PDX1 Co-expression, DAXX/ATRX Mutations, and ALT (Alternative Lengthening of Telomeres).
Endocr Pathol
December 2024
Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Piazzale L.A. Scuro, 10, 37134, Verona, Italy.
Article Synopsis
- Glucagonomas are special tumors in the pancreas that cause a syndrome and were studied in six patients to understand their features better.
- These tumors were mostly large and showed a common skin symptom called necrolytic migratory erythema in all patients.
- The tumors had specific changes in their genes and were linked to serious aggressive behavior, which means they can spread or grow badly in some patients.
Non-functional alpha-cell hyperplasia with glucagon-producing NET: a case report.
Front Endocrinol (Lausanne)
September 2024
Unit for Multidisciplinary Research in Biomedicine (UMIB), School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal.
Article Synopsis
- Alpha-cell hyperplasia (ACH) is a rare pancreatic condition with various forms and is often associated with pancreatic neuroendocrine tumors (pNETs), although its causes are not well understood.
- A 72-year-old male with type 2 diabetes was found to have a non-functioning pNET during treatment for gallbladder issues, which revealed mild glucagon elevation and led to surgery.
- Pathological analysis showed the pNET was glucagon-producing and occurred alongside ACH, emphasizing the need for specialized testing to diagnose such cases even when symptoms suggest a non-functioning tumor.
Manifestations of Endocrine Disease in the Lower Extremities: Beyond the Diabetic Foot.
Int J Low Extrem Wounds
September 2024
Diabetes Centre, Second Department of Internal Medicine, University Hospital of Alexandroupolis, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
Article Synopsis
- The review discusses various endocrine diseases and their effects on the lower extremities, excluding diabetic foot.
- Conditions such as acromegaly, Addison's disease, and thyroid disorders can manifest with distinct clinical signs in this area.
- Early diagnosis through clinical suspicion and treating the endocrine issue typically leads to improvement in symptoms related to the lower extremities.
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