The revised guidelines of the Dutch College of General Practitioners on cholesterol are more in accordance with the consensus guidelines of the Dutch Institute for Health Care Improvement. The number of people with a history of cardiovascular disease who will receive medication is probably underestimated. The guidelines attach little value to diet measurements; however, in individual cases a diet can be a realistic possibility for treatment. Screening for hypercholesterolaemia is now focused more on other risk factors. This and stopping medication in people who have been told in the past they have a treatable disease can turn out to be a problem, for which a national campaign of the public might be helpful.
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Radiat Oncol
January 2025
Department of Radiation Oncology, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China.
Background: Several studies have suggested that lung tissue heterogeneity is associated with overall survival (OS) in lung cancer. However, the quantitative relationship between the two remains unknown. The purpose of this study is to investigate the prognostic value of whole lung-based and tumor-based radiomics for OS in LA-NSCLC treated with definitive radiotherapy.
View Article and Find Full Text PDFLancet Diabetes Endocrinol
January 2025
Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, VIC, Australia; Department of Endocrinology, Monash Health, Clayton, VIC, Australia.
Background: Primary aldosteronism can be treated medically but there is no standardised method to evaluate treatment outcomes. We aimed to develop criteria for assessing the outcomes of targeted medical treatment of primary aldosteronism, analyse outcomes across an international cohort, and identify factors associated with a complete treatment response.
Methods: An international panel of 31 primary aldosteronism experts used the Delphi method to reach consensus on the definition of complete, partial, or absent biochemical and clinical outcomes of medical treatment of primary aldosteronism.
Thromb Haemost
January 2025
Guy's and St Thomas' NHS Foundation Trust, King's College London, United Kingdom.
Background: The benefits and risks of extending anticoagulant treatment beyond the first 3 to 6 months in patients with venous thromboembolism (VTE) in clinical practice are not well understood.
Methods: ETNA-VTE Europe is a prospective, noninterventional, post-authorization study in unselected patients with VTE treated with edoxaban in eight European countries for up to 18 months. Recurrent VTE, major bleeding, and all-cause death were the primary study outcomes.
J Med Syst
January 2025
Intelligent Systems, Delft University of Technology, Delft, The Netherlands.
To equip new counsellors at a Dutch child helpline with the needed counselling skills, the helpline uses role-playing, a form of learning through simulation in which one counsellor-in-training portrays a child seeking help and the other portrays a counsellor. However, this process is time-intensive and logistically challenging-issues that a conversational agent could help address. In this paper, we propose an initial design for a computer agent that acts as a child help-seeker to be used in a role-play setting.
View Article and Find Full Text PDFEur Psychiatry
January 2025
Mental Health Services Noord-Holland-Noord, Alkmaar, the Netherlands; Dutch Clozapine Collaboration Group, Alkmaar, the Netherlands.
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