Gastroesophageal reflux disease (GERD) and laryngitis are common problems in the community. To prove a causal relationship between GERD and laryngitis, one must show the mechanism for acid-induced laryngitis, establish the frequency of association, have a gold standard for diagnosis of the condition, and show that treatment that reduces acid reduces laryngitis in double-blind, randomized, placebo-controlled trials. This article examines each of these components and finds that all are wanting as proof for reflux-induced laryngitis. The best approach to prove the association between GERD and laryngitis will likely lie in well-designed treatment trials.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0002-9343(99)00355-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Weak acid and pepsin reflux induce laryngopharyngeal mucosal barrier injury: A rabbit-model-based study.
PLoS One
January 2025
Department of Otorhinolaryngology, Fujian Provincial Hospital, Fuzhou, Fujian, China.
Objective: Using rabbit models, this study simulated the laryngopharynx's response to the synergistic effects of various acidic reflux environments and pepsin to investigate the response mechanism underlying weak acid reflux and pepsin in the mucosal barrier injury of laryngopharyngeal reflux.
Methods: The rabbits were divided into six groups, and the original larynx was recorded for each group. During the study period, rabbits were sprayed with different doses of acid and pepsin solutions and monitored for hypopharyngeal mucosal transient impedance before and after modeling.
Unlabelled: Children post-tracheoesophageal fistula (TEF) repair may present with chronic respiratory and gastrointestinal symptoms that can affect quality of life.
Objective: To identify factors associated with positive findings on triple endoscopy following neonatal TEF repair.
Study Design: Case series with retrospective review of patients.
Anxiety and Depression Features in Laryngopharyngeal Reflux Disease: A Systematic Review.
J Voice
December 2024
Department of Surgery, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium; Division of Laryngology and Bronchoesophagology, Department of Otolaryngology Head Neck Surgery, EpiCURA Hospital, Baudour, Saint-Ghislain, Belgium; Department of Otolaryngology-Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France; Department of Otolaryngology, Elsan Hospital, Paris, France. Electronic address:
Objective: To investigate the anxiety and depression features in laryngopharyngeal reflux disease (LPRD).
Methods: A laryngologist and librarian conducted a PubMed, Scopus, and Cochrane Library systematic review related to anxiety, depression, and mental health in LPRD through the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statements.
Results: Of the 96 identified studies, 22 publications met the inclusion criteria, accounting for 2162 patients with suspected LPRD (n = 1607), gastroesophageal reflux disease (GERD; n = 423), both LPRD and GERD (n = 132), and 926 healthy/asymptomatic individuals.
Link between pharyngeal acid reflux episodes and the effectiveness of proton pump inhibitor therapy.
World J Gastroenterol
December 2024
School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
Background: Diagnosing laryngopharyngeal reflux (LPR) is challenging due to overlapping symptoms. While proton pump inhibitors (PPIs) are commonly prescribed, reliable predictors of their responsiveness are unclear. Reflux monitoring technologies like dual potential of hydrogen (pH) sensors and multichannel intraluminal impedance-pH (MII-pH) could improve diagnosis.
View Article and Find Full Text PDFRefractory Chronic Cough: A State-of-the-Art Review for Otolaryngologists.
Otolaryngol Head Neck Surg
February 2025
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Article Synopsis
- Patients with refractory chronic cough (RCC) are increasingly visiting otolaryngology clinics, requiring better evaluation and management after standard treatments have failed.
- This review highlights new treatment options for RCC, focusing on disrupting the hypersensitive cough reflex through various methods such as neuromodulators, nerve blockades, and behavioral therapies.
- Understanding these emerging strategies is essential for improving treatment outcomes as more patients seek specialized care for RCC in otolaryngology.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!