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Role of Divalent Ions in Membrane Models of Polymyxin-Sensitive and Resistant Gram-Negative Bacteria.
J Chem Inf Model
January 2025
Central European Institute of Technology, Masaryk University, Brno60200, Czech Republic.
Polymyxins, critical last-resort antibiotics, impact the distribution of membrane-bound divalent cations in the outer membrane of Gram-negative bacteria. We employed atomistic molecular dynamics simulations to model the effect of displacing these ions. Two polymyxin-sensitive and two polymyxin-resistant models of the outer membrane of were investigated.
View Article and Find Full Text PDFMerestinib inhibits cuproptosis by targeting NRF2 to alleviate acute liver injury.
Free Radic Biol Med
January 2025
Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, 214122, China; Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei 230601, China. Electronic address:
The emergence of cuproptosis, a novel form of regulated cell death, is induced by an excess of copper ions and has been associated with the progression of multiple diseases, including liver injury, cardiovascular disease, and neurodegenerative disorders. However, there are currently no inhibitors available for targeting specific cuproptosis-related pathways in therapy. Here, the compound merestinib (MTB) has been identified as a strong inhibitor of cuproptosis through screening of a kinase inhibitor library.
View Article and Find Full Text PDFEffective pretreatment of tea stem via poly-deep eutectic solvent for promoting platform molecule production and obtaining fluorescent lignin.
Int J Biol Macromol
January 2025
College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China; Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, China; Research center of food biotechnology of Xiamen city, Xiamen, Fujian 361021, China. Electronic address:
In this study, polyethylene glycol 200 (PEG200) was employed as hydrogen bond acceptor, while organic acids served as hydrogen bond donors, to formulate poly-deep eutectic solvents (PDESs), which were utilized to pretreat tea stem. Specially, combining PEG200 and oxalic acid (OA) exhibited a notably high cellulose retention (82.03 %) and most efficient hemicellulose (97.
View Article and Find Full Text PDFAntibiotic resistance genes in the coastal atmosphere under varied weather conditions: distribution, influencing factors, and transmission mechanisms.
Environ Pollut
January 2025
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao 266100, PR China; College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, PR China. Electronic address:
Antibiotic resistance genes (ARGs) have escalated to levels of concern worldwide as emerging environmental pollutants. Increasing evidence suggests that non-antibiotic antimicrobial substances expedite the spread of ARGs. However, the drivers and mechanisms involved in the generation and spread of ARGs in the atmosphere remain inadequately elucidated.
View Article and Find Full Text PDFTargeted and untargeted discovery of UV filters and emerging contaminants with environmental risk assessment on the Northwestern Mediterranean coast.
Mar Pollut Bull
January 2025
Sorbonne Université, CNRS, Laboratoire de Biodiversité et Biotechnologie Microbienne, UAR 3579, Observatoire Océanologique, Banyuls-sur-Mer, France. Electronic address:
Marine ecosystems, particularly coastal areas, are becoming increasingly vulnerable to pollution from human activities. Persistent organic pollutants and contaminants of emerging concern (CECs) are recognized as significant threats to both human and environmental health. Our study aimed to identify the molecules present in the seawater of two bathing areas in the Western Mediterranean Sea.
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