Background: The FHIT gene, located at human chromosome 3p14.2, frequently is deleted in a number of human tumors, including breast carcinoma. Its protein product (Fhit) is presumed to have tumor suppressor function. Loss of expression of a tumor suppressor gene is an important step in tumor progression from premalignant, to in situ, to invasive carcinoma.
Methods: In the current study, Fhit expression was examined in invasive carcinomas and in epithelial lesions representing stages of carcinoma progression in 50 mastectomy specimens using immunohistochemical methods.
Results: Normal ductal and lobular epithelium consistently and strongly expressed Fhit. A complete loss of or a significant reduction in Fhit expression was observed in 72% of breast carcinomas. A statistically significant, negative correlation in Fhit expression among the stages of disease progression in Fhit negative breast carcinomas was observed (normal epithelium > hyperplasia > atypical hyperplasia and carcinoma in situ > invasive carcinoma), whereas no loss of Fhit expression in precursor lesions was observed in Fhit positive tumors.
Conclusions: These observations are consistent with the observed role of FHIT as a tumor suppressor gene in the pathogenesis of specific subsets of carcinomas.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
LRP1 involvement in FHIT-regulated HER2 signaling in non-small cell lung cancer.
Eur J Cell Biol
December 2024
Université de Reims Champagne-Ardenne, INSERM, P3Cell, UMR-S 1250, Reims, France. Electronic address:
The tumor suppressor fragile histidine triad (FHIT) is frequently lost in non-small cell lung cancer (NSCLC). We previously showed that a down-regulation of FHIT causes an up-regulation of the activity of HER2 associated to an epithelial-mesenchymal transition (EMT) and that lung tumor cells harboring a FHIT/pHER2 phenotype are sensitive to anti-HER2 drugs. Here, we sought to decipher the FHIT-regulated HER2 signaling pathway in NSCLC.
View Article and Find Full Text PDFDeep joint learning diagnosis of Alzheimer's disease based on multimodal feature fusion.
BioData Min
November 2024
School of Computer Science and Artificial Intelligence, Changzhou University, Changzhou, 213164, China.
Alzheimer's disease (AD) is an advanced and incurable neurodegenerative disease. Genetic variations are intrinsic etiological factors contributing to the abnormal expression of brain function and structure in AD patients. A new multimodal feature fusion called "magnetic resonance imaging (MRI)-p value" was proposed to construct 3D fusion images by introducing genes as a priori knowledge.
View Article and Find Full Text PDFGene expression profiles of neuroinflammatory responses in broad brain regions in rats repeatedly administered with N-methyl-N-nitrosourea for 28 days.
J Toxicol Sci
November 2024
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology.
Article Synopsis
- Exposure to N-methyl-N-nitrosourea (MNU) in rats disrupts neurogenesis in the hippocampus and triggers changes in gene expression across various brain regions.* -
- Analysis revealed that MNU administration led to increased expression of genes associated with immune and inflammatory responses, as well as apoptosis regulation, particularly at the highest dosage of 15 mg/kg.* -
- Immunohistochemical findings indicated that MNU treatment elevated markers for neuroinflammation and oxidative stress, highlighting a dual response in the brain involving both damage and protective mechanisms through activated microglia.*
Loss of miR-200c-3p promotes resistance to radiation therapy via the DNA repair pathway in prostate cancer.
Cell Death Dis
October 2024
Nantes Université, Inserm UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, F-44000, Nantes, France.
Radiotherapy represents a major curative treatment for prostate cancer (PCa), but some patients will develop radioresistance (RR) and relapse. The underlying mechanisms remain poorly understood, and miRNAs might be key players in the acquisition and maintenance of RR. Through their encapsulation in small extracellular vesicles (EVs), they can also be relevant biomarkers of radiation response.
View Article and Find Full Text PDFSignificance and implications of FHIT gene expression and promoter hypermethylation in acute lymphoblastic leukemia (ALL).
Discov Oncol
April 2024
Department of Hematology, SKIMS, Srinagar, 190011, J&K, India.
Background: Fragile histidine triad (FHIT) has been documented to play a vital role in various cancers including acute lymphoblastic leukemia (ALL). Keeping in view the plausible role of FHIT gene, we aimed to examine DNA promoter hypermethylation and mRNA expression in ALL cases in Kashmir (North India).
Methods: A total of 66 cases of ALL were analyzed for FHIT mRNA expression and promoter methylation by qRT-PCR and Methylation Specific-PCR (MS-PCR) respectively.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!