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MPOX is an orthopoxvirus whose infection has been declared a Public Health Emergency of International Concern in 2022 and 2024. It proved to be a virus with markedly heterogeneous and varied clinical presentation. We performed a systematic PubMed review of articles reporting cases of different clinical manifestations of MPOX until October 2024.
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Alzheimers Dement
December 2024
Ahmadu Bello University, Zaria, Kaduna, Nigeria.
Background: Sleep deprivation leads to an increase in oxidative stress and activation of inflammatory response and both could increase the production and accumulation of toxic beta-amyloid in the hippocampus which is considered one of the molecular drivers of Alzheimer's pathogenesis and progression. Despite these findings, obtaining sleep is still challenging in our modern society that values work around the clock. Omega-3 fatty acids represents an active biological agent with vital antioxidant and anti-inflammatory activities that could protect memory in the face of insufficient sleep.
View Article and Find Full Text PDFPhysiologically Based Pharmacokinetic Modeling of Cannabidiol, Delta-9-Tetrahydrocannabinol, and Their Metabolites in Healthy Adults After Administration by Multiple Routes.
Clin Transl Sci
January 2025
Department of Chemistry, York College, City University of New York, New York, USA.
The two most extensively studied cannabinoids, cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), are used for myriad conditions. THC is predominantly eliminated via the cytochromes P450 (CYPs), whereas CBD is eliminated through both CYPs and UDP-glucuronosyltransferases (UGTs). The fractional contributions of these enzymes to cannabinoid metabolism have shown conflicting results among studies.
View Article and Find Full Text PDFSoft cluster-rectangle method for eliciting criteria weights in multi-criteria decision-making.
Sci Rep
January 2025
Institute of Sustainable Construction, Vilnius Gediminas Technical University, Vilnius, Lithuania.
Subjective weighting methods are widely employed to determine criteria weights in multi-criteria decision-making (MCDM) environment. Inputs from decision-makers, including opinions, assessments, assumptions, evaluations, interpretations, expectations, and judgments, are primarily relied upon in these methods. Significant challenges are faced due to two primary factors: the inherent uncertainty in inputs and the process of pairwise comparisons.
View Article and Find Full Text PDFCompressible, anti-fatigue, extreme environment adaptable, and biocompatible supramolecular organohydrogel enabled by lignosulfonate triggered noncovalent network.
Nat Commun
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Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Hubei Provincial Engineering Research Center of Emerging Functional Coating Materials, School of Resource and Environmental Sciences, Wuhan University, Wuhan, 430079, China.
Achieving a synergy of biocompatibility and extreme environmental adaptability with excellent mechanical property remains challenging in the development of synthetic materials. Herein, a "bottom-up" solution-interface-induced self-assembly strategy is adopted to develop a compressible, anti-fatigue, extreme environment adaptable, biocompatible, and recyclable organohydrogel composed of chitosan-lignosulfonate-gelatin by constructing noncovalent bonded conjoined network. The ethylene glycol/water solvent induced lignosulfonate nanoparticles function as bridge in chitosan/gelation network, forming multiple interfacial interactions that can effectively dissipate energy.
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