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Embracing the Future of Clinical Trials in Radiotherapy: An NRG Oncology CIRO Technology Retreat Whitepaper on Pioneering Technologies and AI-Driven Solutions.
Int J Radiat Oncol Biol Phys
January 2025
National Cancer Institute, Bethesda, MD. Electronic address:
This white paper examines the potential of pioneering technologies and artificial intelligence (AI)-driven solutions in advancing clinical trials involving radiotherapy. As the field of radiotherapy evolves, the integration of cutting-edge approaches such as radiopharmaceutical dosimetry, FLASH radiotherapy, image-guided radiation therapy (IGRT), and AI promises to improve treatment planning, patient care, and outcomes. Additionally, recent advancements in quantum science, linear energy transfer/relative biological effect (LET/RBE), and the combination of radiotherapy and immunotherapy create new avenues for innovation in clinical trials.
View Article and Find Full Text PDFAccuracy Evaluation of Dose Warping Using Deformable Image Registration in Carbon Ion Therapy.
Int J Part Ther
March 2025
Department of Heavy Particle Medical Science, Yamagata University Graduate School of Medical Science, Yamagata, Japan.
Purpose: The study's purpose was to use a simple geometry phantom to validate the deformable image registration (DIR) accuracy and dose warping accuracy in carbon ion radiotherapy (CIRT) and to provide an index for dosimetry in CIRT.
Materials And Methods: We used geometric and anatomical phantoms provided by AAPM TG-132. The DIRs of 3 different settings were performed between reference and translational images for each phantom.
A feasibility study on a small electron linear accelerator-based beam shaping assembly for boron neutron capture therapy.
Appl Radiat Isot
March 2025
Kyoto University Graduate School of Engineering, Kyoto Daigaku-katsura, Nishikyo-ku, Kyoto, 615-8530, Japan.
We aimed to explore the possibility of realizing a beam shaping assembly (BSA) driven by a 15-kW beam of 33-MeV electrons of an electron linear accelerator (LINAC) when a boronophenylalanine is adopted as a boron carrier. Simulation calculations were performed to design two types of BSAs driven by the small LINAC. The one was an experimental BSA, and the other was a high-performance BSA.
View Article and Find Full Text PDFSpectral gamma ray borehole logging data can yield insights into the physical properties of lake sediments, serving as a valuable proxy for assessing climate and environmental changes. The presence of tephra layers resulting from volcanic ash deposition is not related to climate and environmental conditions. As a result, these layers pose challenges when attempting to analyze paleoclimate and environmental time series.
View Article and Find Full Text PDFFast spot order optimization to increase dose rates in scanned particle therapy FLASH treatments.
Phys Med Biol
January 2025
Research, RaySearch Laboratories, Stockholm, Sweden.
The advent of ultra-high dose rate irradiation, known as FLASH radiation therapy, has shown promising potential in reducing toxicity while maintaining tumor control. However, the clinical translation of these benefits necessitates efficient treatment planning strategies. This study introduces a novel approach to optimize proton therapy for FLASH effects using traveling salesperson problem (TSP) heuristics.
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